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高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (2): 284-288.doi: 10.1007/s40242-014-3421-7

• Articles • 上一篇    下一篇

Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate

GUAN Ruqi, CHAO Guoku, YE Caiping, WANG Yuxiang, LIU Yanmei, LI Haihua, ZHAO Yajuan, TAI Yulei   

  1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P. R. China
  • 收稿日期:2013-10-08 修回日期:2013-11-20 出版日期:2014-04-01 发布日期:2013-12-30
  • 通讯作者: ZHAO Yajuan, TAI Yulei E-mail:zyj@wzu.edu.cn;wzunuannuan@126.com
  • 基金资助:

    Supported by the Fund of Science &; Technological Project of Zhejiang Province, China(No.2009C33059), the Discipline Construction Project of Wenzhou University, China(No.316406125020301) and the Zhejiang Provincial Top Key Discipline of New Materials and Process Engineering, China(No.20110949).

Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate

GUAN Ruqi, CHAO Guoku, YE Caiping, WANG Yuxiang, LIU Yanmei, LI Haihua, ZHAO Yajuan, TAI Yulei   

  1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P. R. China
  • Received:2013-10-08 Revised:2013-11-20 Online:2014-04-01 Published:2013-12-30
  • Contact: ZHAO Yajuan, TAI Yulei E-mail:zyj@wzu.edu.cn;wzunuannuan@126.com
  • Supported by:

    Supported by the Fund of Science &; Technological Project of Zhejiang Province, China(No.2009C33059), the Discipline Construction Project of Wenzhou University, China(No.316406125020301) and the Zhejiang Provincial Top Key Discipline of New Materials and Process Engineering, China(No.20110949).

摘要：

Ru-B/γ-Al2O3 catalyst was prepared by reductant impregnation method, which was applied in the selective hydrogenation of ethyl 1H-indole-2-carboxylate for producing ethyl 2,3,3a,7a-tetrahydro-1H-indole-2-carboxylate with hydrogen as reductant. Furthermore, we discussed the influences of substrate concentration, reaction solvent, hydrogenation temperature, initial hydrogen pressure and reaction time on the catalytic performance of the as-prepared catalyst. The obtained Ru-B/γ-Al2O3 catalyst showed a high-efficiency for the selective hydrogenation of ethyl 1H-indole-2-carboxylate(>99% conversion and selectivity) in i-propanol used as solvent at a concentration of 10%(mass fraction) of ethyl 1H-indole-2-carboxylate, a pressure of hydrogen of 6 MPa and a reaction temperature of 373 K.

关键词: Selective hydrogenation, Supported amorphous catalyst, Ru-B/γ-Al2O3, Indole derivative

Abstract:

Ru-B/γ-Al2O3 catalyst was prepared by reductant impregnation method, which was applied in the selective hydrogenation of ethyl 1H-indole-2-carboxylate for producing ethyl 2,3,3a,7a-tetrahydro-1H-indole-2-carboxylate with hydrogen as reductant. Furthermore, we discussed the influences of substrate concentration, reaction solvent, hydrogenation temperature, initial hydrogen pressure and reaction time on the catalytic performance of the as-prepared catalyst. The obtained Ru-B/γ-Al2O3 catalyst showed a high-efficiency for the selective hydrogenation of ethyl 1H-indole-2-carboxylate(>99% conversion and selectivity) in i-propanol used as solvent at a concentration of 10%(mass fraction) of ethyl 1H-indole-2-carboxylate, a pressure of hydrogen of 6 MPa and a reaction temperature of 373 K.

Key words: Selective hydrogenation, Supported amorphous catalyst, Ru-B/γ-Al2O3, Indole derivative