Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

高等学校化学研究 ›› 2002, Vol. 18 ›› Issue (1): 16-19.

Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

DENG Guang-hui¹, WEI Shou-lian¹, MO Jin-yuan²

1. Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry, Zhongshan University, Guangzhou 510275, P. R. China

收稿日期:2000-10-18 出版日期:2002-01-24 发布日期:2011-08-04
基金资助:
Supported by the Natural Science Foundation of Guangxi Province(No.9912001).

Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

DENG Guang-hui¹, WEI Shou-lian¹, MO Jin-yuan²

1. Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry, Zhongshan University, Guangzhou 510275, P. R. China

Received:2000-10-18 Online:2002-01-24 Published:2011-08-04
Supported by:
Supported by the Natural Science Foundation of Guangxi Province(No.9912001).

摘要/Abstract

摘要： In the nonaqueous N,N-dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl-β-cyclodextrin(s-β-CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS(β-CD, diethylic-β-CD, sulfonyl-β-CD) on the chiral separation was made and the resolution mechanism was proposed.

关键词: Nonaqueous medium, Capillary electrophoresis with conductance detection, Sulfonyl &beta, -CD, Resolution, N, N-Dimethylformamide

Abstract: In the nonaqueous N,N-dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl-β-cyclodextrin(s-β-CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS(β-CD, diethylic-β-CD, sulfonyl-β-CD) on the chiral separation was made and the resolution mechanism was proposed.

Key words: Nonaqueous medium, Capillary electrophoresis with conductance detection, Sulfonyl β-CD, Resolution, N,N-Dimethylformamide

DENG Guang-hui, WEI Shou-lian, MO Jin-yuan. Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection[J]. 高等学校化学研究, 2002, 18(1): 16-19.

DENG Guang-hui, WEI Shou-lian, MO Jin-yuan. Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection[J]. Chemical Research in Chinese Universities, 2002, 18(1): 16-19.

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Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

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