Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (2): 178-185.

Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

TIAN Xiao-bing¹, ZHANG Ling¹, MIN Ji-mei¹, ZHANG Li-he¹, LU Yang², JIANG Reng-wang², ZHENG Qi-tai²

1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China;
2. Institute of Materia Medica, Peking Union Medical College ＆Chinese Academy of Medical Sciences, Beijing 100050, P. R. China

收稿日期:2000-05-01 出版日期:2001-04-24 发布日期:2011-08-04
基金资助:
Bicyclic isonucleoside|Locked conformation|Synthesis

Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

TIAN Xiao-bing¹, ZHANG Ling¹, MIN Ji-mei¹, ZHANG Li-he¹, LU Yang², JIANG Reng-wang², ZHENG Qi-tai²

1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China;
2. Institute of Materia Medica, Peking Union Medical College ＆Chinese Academy of Medical Sciences, Beijing 100050, P. R. China

Received:2000-05-01 Online:2001-04-24 Published:2011-08-04
Supported by:
Supported by the National Natural Science Foundation of China

摘要/Abstract

摘要： Novel bicyclic isonucleosides, 2'-deoxy- 2'-nucleobase- 5'-deoxy- 1', 4': 3', 6'-dianhydro D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con formation.

关键词: Bicyclic isonucleoside, Locked conformation, Synthesis

Abstract: Novel bicyclic isonucleosides, 2'-deoxy- 2'-nucleobase- 5'-deoxy- 1', 4': 3', 6'-dianhydro D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con formation.

Key words: Bicyclic isonucleoside, Locked conformation, Synthesis

TIAN Xiao-bing, ZHANG Ling, MIN Ji-mei, ZHANG Li-he, LU Yang, JIANG Reng-wang, ZHENG Qi-tai. Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol[J]. 高等学校化学研究, 2001, 17(2): 178-185.

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Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

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