Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

高等学校化学研究 ›› 2006, Vol. 22 ›› Issue (5): 593-597.doi:

Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

GAO Fei-fei, LI Yao-xian, ZHANG Suo-qin and ZHANG Guang-liang

College of Chemistry, Jilin University, Changchun 130021, P. R. China

收稿日期:2005-09-07 修回日期:1900-01-01 出版日期:2006-09-25 发布日期:2006-09-25
通讯作者: ZHANG Suo-qin E-mail:zhangsq@jlu.edu.cn

Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

GAO Fei-fei, LI Yao-xian, ZHANG Suo-qin and ZHANG Guang-liang

College of Chemistry, Jilin University, Changchun 130021, P. R. China

Received:2005-09-07 Revised:1900-01-01 Online:2006-09-25 Published:2006-09-25
Contact: ZHANG Suo-qin E-mail:zhangsq@jlu.edu.cn

摘要/Abstract

摘要：

关键词: Sulfonylaminocarbonyl-2-thiohydantoin, Sulfonylurea, Acetohydroxyacid synthase, Herbicidal activity

Abstract: A novel kind of acetohydroxyacid synthase(AHAS) inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5-methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.

Key words: Sulfonylaminocarbonyl-2-thiohydantoin, Sulfonylurea, Acetohydroxyacid synthase, Herbicidal activity, Sulfonylaminocarbonyl-2-thiohydantoin, Sulfonylurea, Acetohydroxyacid synthase, Herbicidal activity

GAO Fei-fei, LI Yao-xian, ZHANG Suo-qin , ZHANG Guang-liang. Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors[J]. 高等学校化学研究, 2006, 22(5): 593-597.

GAO Fei-fei, LI Yao-xian, ZHANG Suo-qin , ZHANG Guang-liang. Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors[J]. Chemical Research in Chinese Universities, 2006, 22(5): 593-597.

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Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

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