[an error occurred while processing this directive]

高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (1): 32-35.

• Articles • 上一篇    下一篇

Polarographic Studies on Associations of Midecamycin and Chloroquine with Hydrogen Peroxide

LI Ning1, SONG Jun-feng1, XU Mao-tian1, ZHANG Ya2   

  1. 1. Institute of Analytical Science, Northwest University, Xi′an 710069, P. R. China;
    2. Department of Chemistry, Suide Teachers′ School, Suide 718000, P. R. China
  • 收稿日期:2003-12-14 出版日期:2005-01-24 发布日期:2011-07-27
  • 基金资助:

    Supported by the National Natural Science Foundation of P.R.China(No.20475043) and the Natural Science Foundation of Shaanxi Province(No.2002B01).

Polarographic Studies on Associations of Midecamycin and Chloroquine with Hydrogen Peroxide

LI Ning1, SONG Jun-feng1, XU Mao-tian1, ZHANG Ya2   

  1. 1. Institute of Analytical Science, Northwest University, Xi′an 710069, P. R. China;
    2. Department of Chemistry, Suide Teachers′ School, Suide 718000, P. R. China
  • Received:2003-12-14 Online:2005-01-24 Published:2011-07-27
  • Supported by:

    Supported by the National Natural Science Foundation of P.R.China(No.20475043) and the Natural Science Foundation of Shaanxi Province(No.2002B01).

PDF (PC)

摘要： The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography.In a 0.15 mol/L KH2PO4-NaOH(pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1∶1, and the apparent association constant is 7.18.While in a 0.04 mol/L NH3·H2O-NH4Cl(pH 9.5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1∶1 and 45.4, respectively.The formation of the association complexes stabilizes H2O2 and results in the accumulation of H2O2, which is baneful to human body.

关键词: Midecamycin, Chloroquine phosphate, Hydrogen peroxide, Association, Linear-potential scan polarography, Reactive oxygen species

Abstract: The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography.In a 0.15 mol/L KH2PO4-NaOH(pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1∶1, and the apparent association constant is 7.18.While in a 0.04 mol/L NH3·H2O-NH4Cl(pH 9.5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1∶1 and 45.4, respectively.The formation of the association complexes stabilizes H2O2 and results in the accumulation of H2O2, which is baneful to human body.

Key words: Midecamycin, Chloroquine phosphate, Hydrogen peroxide, Association, Linear-potential scan polarography, Reactive oxygen species