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高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (4): 708-711.

• Articles • 上一篇    下一篇

Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes

WU Li-li, LI Xiao-ran, LI Hua and YUAN Xiao-yan*   

  1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China
  • 收稿日期:2010-07-29 修回日期:2011-04-29 出版日期:2011-07-25 发布日期:2011-06-29
  • 通讯作者: YUAN Xiao-yan E-mail:yuanxy@tju.edu.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China(Nos.50273027, 50573055, 30828008) and the Natural Science Foundation of Tianjin City, China(No.09JCZDJC18600).

Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes

WU Li-li, LI Xiao-ran, LI Hua and YUAN Xiao-yan*   

  1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China
  • Received:2010-07-29 Revised:2011-04-29 Online:2011-07-25 Published:2011-06-29
  • Contact: YUAN Xiao-yan E-mail:yuanxy@tju.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.50273027, 50573055, 30828008) and the Natural Science Foundation of Tianjin City, China(No.09JCZDJC18600).

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摘要： In order to encapsulate and controlled-release bioactive proteins, three fibrous membranes, i.e.,      poly(L-lactide-co-glycolide)(PLGA), hybrid PLGA and chitosan(H-PLGA/CS), and core/shell PLGA/CS (C-PLGA/CS), were produced by emulsion electrospinning, co-electrospinning and coaxial electrospinning, respectively. Bovine serum albumin(BSA) was selected as a model protein. The loading efficiency of BSA in the PLGA membrane was 1.56%, lower than those of H-PLGA/CS(5.98%) and C-PLGA/CS(4.80%). BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d. Cumulative releases at the end of the releasing period, 28 d, from the above three membranes were nearly 63%, 88% and 94%, respectively, indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate. In addition, all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.

关键词: Controlled release, Bovine serum albumin, Electrospun membrane, Poly(L-lactide-co-glycolide), Chitosan

Abstract: In order to encapsulate and controlled-release bioactive proteins, three fibrous membranes, i.e.,      poly(L-lactide-co-glycolide)(PLGA), hybrid PLGA and chitosan(H-PLGA/CS), and core/shell PLGA/CS (C-PLGA/CS), were produced by emulsion electrospinning, co-electrospinning and coaxial electrospinning, respectively. Bovine serum albumin(BSA) was selected as a model protein. The loading efficiency of BSA in the PLGA membrane was 1.56%, lower than those of H-PLGA/CS(5.98%) and C-PLGA/CS(4.80%). BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d. Cumulative releases at the end of the releasing period, 28 d, from the above three membranes were nearly 63%, 88% and 94%, respectively, indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate. In addition, all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.

Key words: Controlled release, Bovine serum albumin, Electrospun membrane, Poly(L-lactide-co-glycolide), Chitosan