Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model

doi:10.1007/s40242-015-5295-8

高等学校化学研究 ›› 2016, Vol. 32 ›› Issue (2): 302-310.doi: 10.1007/s40242-015-5295-8

Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model

LIU Yabo, XU Yihan, ZHAO Yaru, JIA Yuxi

Key Laboratory for Liquid-solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, P. R. China

收稿日期:2015-07-22 修回日期:2015-09-14 出版日期:2016-04-01 发布日期:2015-11-02
通讯作者: JIA Yuxi E-mail:jia_yuxi@sdu.edu.cn
基金资助:
Supported by the National Key Basic Research Program of China(No.2012CB821500).

Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model

LIU Yabo, XU Yihan, ZHAO Yaru, JIA Yuxi

Key Laboratory for Liquid-solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, P. R. China

Received:2015-07-22 Revised:2015-09-14 Online:2016-04-01 Published:2015-11-02
Contact: JIA Yuxi E-mail:jia_yuxi@sdu.edu.cn
Supported by:
Supported by the National Key Basic Research Program of China(No.2012CB821500).

摘要/Abstract

摘要：

In different parts of the gastrointestinal tract, the rate of drug release from polyelectrolyte hydrogel tablets is highly affected by variance of ionic concentration. This research aims at revealing clearly how the drug release from a hydrogel matrix is affected by ionic concentration of external solution through the finite element simulation and triphasic mechanism model. The coupled relationship of the motions including the polyelectrolyte hydrogel swelling, the water flow and the ion diffusion, is illustrated in the present work. In order to simulate the drug controlled release from a swollen polyelectrolyte hydrogel carrier, the mathematical model was built on the basis of the multiphasic theory of polyelectrolyte hydrogels. Finally, the reliability of the simulation method was verified qualitatively by experimental results. The results reveal that when the initial concentration of fixed anions of polymer network is higher than the concentration of free anions in the external solution, the drug release rate increases with increasing the ionic concentration of the external solution. The research is helpful for the optimal design of oral drug release in gastrointestinal tract.

关键词: Polyelectrolyte hydrogel carrier, Triphasic mechanism model, Drug controlled release, Finite element simulation, Mathematical model

Abstract:

Key words: Polyelectrolyte hydrogel carrier, Triphasic mechanism model, Drug controlled release, Finite element simulation, Mathematical model

LIU Yabo, XU Yihan, ZHAO Yaru, JIA Yuxi. Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model[J]. 高等学校化学研究, 2016, 32(2): 302-310.

LIU Yabo, XU Yihan, ZHAO Yaru, JIA Yuxi. Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model[J]. Chemical Research in Chinese Universities, 2016, 32(2): 302-310.

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Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model

Effect of Ionic Concentration on Drug Release from Polyelectrolyte Hydrogel Carriers Analyzed via Triphasic Mechanism Model

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