Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

doi:10.1007/s40242-025-4234-6

高等学校化学研究 ›› 2025, Vol. 41 ›› Issue (2): 305-312.doi: 10.1007/s40242-025-4234-6

Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

ZENG Qingbin^1,2, WANG Zhen^1,2, GUO Qianni^1,2, SONG Wei^1,2, ZHAO Xiuchao^1,2, YANG Yuqi^1,2, ZHOU Xin^1,2

1. State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, P. R. China;
2. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

收稿日期:2024-12-09 接受日期:2024-01-22 出版日期:2025-04-01 发布日期:2025-03-31
通讯作者: GUO Qianni,qian-niguo@wipm.ac.cn;ZHOU Xin,xinzhou@wipm.ac.cn E-mail:qian-niguo@wipm.ac.cn;xinzhou@wipm.ac.cn
基金资助:
This work was supported by the National Natural Science Foundation of China (Nos. 82127802, 21921004), the Strategic Priority Research Program of CAS (No. XDB0540000), the Key Research Program of Frontier Sciences of CAS (No. ZDBS-LY-JSC004), the Key Technology Foundation of Hubei Province, China (No. 2021ACA013), the Major Program (JD) of Hubei Province, China (No. 2023BAA021), the CAS Fund for the Youth Interdisciplinary Team, China (No. JCTD-2022-13), the Youth Innovation Promotion Association of CAS (No. 2023347), the Wuhan Talent Project, China, and the Natural Science Foundation of Hubei Province, China (No. 2023AFB790).

Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

ZENG Qingbin^1,2, WANG Zhen^1,2, GUO Qianni^1,2, SONG Wei^1,2, ZHAO Xiuchao^1,2, YANG Yuqi^1,2, ZHOU Xin^1,2

1. State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, P. R. China;
2. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Received:2024-12-09 Accepted:2024-01-22 Online:2025-04-01 Published:2025-03-31
Contact: GUO Qianni,qian-niguo@wipm.ac.cn;ZHOU Xin,xinzhou@wipm.ac.cn E-mail:qian-niguo@wipm.ac.cn;xinzhou@wipm.ac.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (Nos. 82127802, 21921004), the Strategic Priority Research Program of CAS (No. XDB0540000), the Key Research Program of Frontier Sciences of CAS (No. ZDBS-LY-JSC004), the Key Technology Foundation of Hubei Province, China (No. 2021ACA013), the Major Program (JD) of Hubei Province, China (No. 2023BAA021), the CAS Fund for the Youth Interdisciplinary Team, China (No. JCTD-2022-13), the Youth Innovation Promotion Association of CAS (No. 2023347), the Wuhan Talent Project, China, and the Natural Science Foundation of Hubei Province, China (No. 2023AFB790).

摘要/Abstract

摘要： Hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI) is a powerful tool for detecting respiratory system diseases. However, ¹²⁹Xe is an inert gas and lacks specific detection capability. Entrapping xenon within molecular cages to enable specific detection is a challenging task, and numerous molecular cages have been developed and evaluated to address this challenge. Herein, we report that the aluminum-based metal-organic framework, CAU-1, can effectively entrap xenon for hyperpolarized ¹²⁹Xe MRI in aqueous solutions. This platform exhibits high water stability and good dispersibility, and shows excellent xenon entrapment capability, even at a concentration as low as 50 μg/mL. Importantly, it is responsive to pH changes across a range from 6.6 to 5.0, making it promising for monitoring the weakly acidic environment in tumors or metabolic abnormality. Furthermore, the scalable and cost-effective production of this molecular cage will facilitate future advancements in molecular imaging and chemical sensing applications.

关键词: Metal-organic framework (MOF), Hyperpolarization, Magnetic resonance imaging (MRI)

Abstract: Hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI) is a powerful tool for detecting respiratory system diseases. However, ¹²⁹Xe is an inert gas and lacks specific detection capability. Entrapping xenon within molecular cages to enable specific detection is a challenging task, and numerous molecular cages have been developed and evaluated to address this challenge. Herein, we report that the aluminum-based metal-organic framework, CAU-1, can effectively entrap xenon for hyperpolarized ¹²⁹Xe MRI in aqueous solutions. This platform exhibits high water stability and good dispersibility, and shows excellent xenon entrapment capability, even at a concentration as low as 50 μg/mL. Importantly, it is responsive to pH changes across a range from 6.6 to 5.0, making it promising for monitoring the weakly acidic environment in tumors or metabolic abnormality. Furthermore, the scalable and cost-effective production of this molecular cage will facilitate future advancements in molecular imaging and chemical sensing applications.

Key words: Metal-organic framework (MOF), Hyperpolarization, Magnetic resonance imaging (MRI)

ZENG Qingbin, WANG Zhen, GUO Qianni, SONG Wei, ZHAO Xiuchao, YANG Yuqi, ZHOU Xin. Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution[J]. 高等学校化学研究, 2025, 41(2): 305-312.

ZENG Qingbin, WANG Zhen, GUO Qianni, SONG Wei, ZHAO Xiuchao, YANG Yuqi, ZHOU Xin. Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution[J]. Chemical Research in Chinese Universities, 2025, 41(2): 305-312.

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Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

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