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高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (6): 1151-1152.doi: 10.1007/s40242-020-0352-3

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Meta-DNA Strategy to Assemble DNA Structures in Submicrometre and Micrometre Scale

KONG Deming   

  1. Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
  • 收稿日期:2020-10-30 修回日期:2020-11-04 出版日期:2020-12-01 发布日期:2020-10-30
  • 通讯作者: KONG Deming E-mail:kongdem@nankai.edu.cn

Meta-DNA Strategy to Assemble DNA Structures in Submicrometre and Micrometre Scale

KONG Deming   

  1. Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
  • Received:2020-10-30 Revised:2020-11-04 Online:2020-12-01 Published:2020-10-30
  • Contact: KONG Deming E-mail:kongdem@nankai.edu.cn

摘要： To break through the size limitation in DNA structure assembly and to achieve the construction of DNA structures with submicrometre and micrometre scale, Fan and Yan et al. proposed a versatile DNA structure assembly strategy, named as meta-DNA(M-DNA) strategy. Submicrometre-sized M-DNA, which has a six-helix bundle DNA origami nanostructure, is used as building block to precisely assemble a series of submicrometre-to-micrometre-sized DNA architectures with customed shapes, including meta-multi-arm junctions, polyhedrons and closely packed lattices. Besides static assembly, the proposed M-DNA strategy was also demonstrated to work well for the programmed dynamic rearrangement of DNA structures. This work has been published online in the Nature Chemistry on September 7, 2020.

Abstract: To break through the size limitation in DNA structure assembly and to achieve the construction of DNA structures with submicrometre and micrometre scale, Fan and Yan et al. proposed a versatile DNA structure assembly strategy, named as meta-DNA(M-DNA) strategy. Submicrometre-sized M-DNA, which has a six-helix bundle DNA origami nanostructure, is used as building block to precisely assemble a series of submicrometre-to-micrometre-sized DNA architectures with customed shapes, including meta-multi-arm junctions, polyhedrons and closely packed lattices. Besides static assembly, the proposed M-DNA strategy was also demonstrated to work well for the programmed dynamic rearrangement of DNA structures. This work has been published online in the Nature Chemistry on September 7, 2020.