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高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (6): 1147-1148.doi: 10.1007/s40242-020-0325-6

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A DNA Nanodevice for Cancer Vaccination

ZUO Hua1, MAO Chengde2   

  1. 1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P. R. China;
    2. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States
  • 收稿日期:2020-10-10 修回日期:2020-10-12 出版日期:2020-12-01 发布日期:2020-10-12
  • 通讯作者: ZUO Hua, MAO Chengde E-mail:zuohua@swu.edu.cn;mao@purdue.edu

A DNA Nanodevice for Cancer Vaccination

ZUO Hua1, MAO Chengde2   

  1. 1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P. R. China;
    2. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States
  • Received:2020-10-10 Revised:2020-10-12 Online:2020-12-01 Published:2020-10-12
  • Contact: ZUO Hua, MAO Chengde E-mail:zuohua@swu.edu.cn;mao@purdue.edu

摘要: To realize effective cancer immunotherapy, Ding et al. constructed a structurally well-defined DNA-based nanodevice to quantitatively assemble cancer cell-specific antigen and multiple adjuvants as a cancer vaccine. This nanodevice vaccine can efficiently accumulate in the draining lymph nodes and respond to the endosomal acidic environment of dendritic cells to release the antigen and adjuvants. These active payloads stimulate dendritic cells maturation and antigen presentation to elicit a robust, antigen-specific cytotoxic T-lymphocyte response to kill cancer cells. This work has been published online in the Nature Materials on Sept.7, 2020.

Abstract: To realize effective cancer immunotherapy, Ding et al. constructed a structurally well-defined DNA-based nanodevice to quantitatively assemble cancer cell-specific antigen and multiple adjuvants as a cancer vaccine. This nanodevice vaccine can efficiently accumulate in the draining lymph nodes and respond to the endosomal acidic environment of dendritic cells to release the antigen and adjuvants. These active payloads stimulate dendritic cells maturation and antigen presentation to elicit a robust, antigen-specific cytotoxic T-lymphocyte response to kill cancer cells. This work has been published online in the Nature Materials on Sept.7, 2020.