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高等学校化学研究 ›› 2019, Vol. 35 ›› Issue (2): 235-238.doi: 10.1007/s40242-019-8277-4

• Articles • 上一篇    下一篇

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

JIANG Ling, YE Wenting, SU Weike   

  1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China
  • 收稿日期:2018-09-03 修回日期:2018-10-31 出版日期:2019-04-01 发布日期:2019-04-30
  • 通讯作者: SU Weike E-mail:pharmlab@zjut.edu.cn
  • 基金资助:
    Supported by the National Natural Science Foundation of China(No.21706236), the China Postdoctoral Science Foundation (No.2016M592012) and the Foundation for Selected Postdoctoral Project of Zhejiang Province, China(No.BSH1502150).

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

JIANG Ling, YE Wenting, SU Weike   

  1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China
  • Received:2018-09-03 Revised:2018-10-31 Online:2019-04-01 Published:2019-04-30
  • Contact: SU Weike E-mail:pharmlab@zjut.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21706236), the China Postdoctoral Science Foundation (No.2016M592012) and the Foundation for Selected Postdoctoral Project of Zhejiang Province, China(No.BSH1502150).

摘要： A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.

关键词: Porcine pancreatic lipase, Biocatalysis, One-pot synthesis, Higly functionalized 1,4-dihydropyridines

Abstract: A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.

Key words: Porcine pancreatic lipase, Biocatalysis, One-pot synthesis, Higly functionalized 1,4-dihydropyridines