2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

doi:10.1007/s40242-015-4495-6

高等学校化学研究 ›› 2015, Vol. 31 ›› Issue (3): 321-324.doi: 10.1007/s40242-015-4495-6

2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

YANG Jianxin^1,2, YIN Yunxing², HE Zhenmin², MA Li², LI Xin², ZHANG Zhiliu², LIN Xiaojuan², MA Rujian²

1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China;
2. WuXi PharmaTech Co. Ltd., Shanghai 200131, P. R. China

收稿日期:2014-12-18 修回日期:2015-01-16 出版日期:2015-06-01 发布日期:2015-04-13
通讯作者: MA Rujian E-mail:marj@wuxiapptec.com
基金资助:
Supported by the National Natural Science Foundation of China(No.51209024).

2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

YANG Jianxin^1,2, YIN Yunxing², HE Zhenmin², MA Li², LI Xin², ZHANG Zhiliu², LIN Xiaojuan², MA Rujian²

1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China;
2. WuXi PharmaTech Co. Ltd., Shanghai 200131, P. R. China

Received:2014-12-18 Revised:2015-01-16 Online:2015-06-01 Published:2015-04-13
Contact: MA Rujian E-mail:marj@wuxiapptec.com
Supported by:
Supported by the National Natural Science Foundation of China(No.51209024).

摘要/Abstract

摘要：

An efficient one-pot synthesis of α-hydroxy esters by employing the useful reagent 2-hydroxymalononitrile reacting with an aldehyde or ketone in just one step has been reported.

关键词: α-Hydroxy ester, One-pot synthesis, 2-Hydroxymalononitrile

Abstract:

An efficient one-pot synthesis of α-hydroxy esters by employing the useful reagent 2-hydroxymalononitrile reacting with an aldehyde or ketone in just one step has been reported.

Key words: α-Hydroxy ester, One-pot synthesis, 2-Hydroxymalononitrile

YANG Jianxin, YIN Yunxing, HE Zhenmin, MA Li, LI Xin, ZHANG Zhiliu, LIN Xiaojuan, MA Rujian. 2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters[J]. 高等学校化学研究, 2015, 31(3): 321-324.

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2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

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