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高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (3): 396-399.doi: 10.1007/s40242-014-3442-2

• Articles • 上一篇    下一篇

Enzymatic Promiscuity：“Amano” Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media

JIANG Ling, YU Hongwei   

  1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, P. R. China
  • 收稿日期:2013-10-15 修回日期:2013-11-15 出版日期:2014-06-01 发布日期:2013-12-11
  • 通讯作者: YU Hongwei E-mail:yuhongwei@zju.edu.cn
  • 基金资助:

    Supported by the Program for Zhejiang Leading Team of Science & Technology Innovation, China(No.2011R50007), the National Natural Science Foundation of China(Nos.21176215, 21176102) and the Outstanding Young Scholar Grant of Zhejiang University, China(No.R4110092).

Enzymatic Promiscuity：“Amano” Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media

JIANG Ling, YU Hongwei   

  1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, P. R. China
  • Received:2013-10-15 Revised:2013-11-15 Online:2014-06-01 Published:2013-12-11
  • Contact: YU Hongwei E-mail:yuhongwei@zju.edu.cn
  • Supported by:

    Supported by the Program for Zhejiang Leading Team of Science & Technology Innovation, China(No.2011R50007), the National Natural Science Foundation of China(Nos.21176215, 21176102) and the Outstanding Young Scholar Grant of Zhejiang University, China(No.R4110092).

摘要：

"Amano" lipase AS(lipase from Aspergillus niger), which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.

关键词: “Amano&rdquo, lipase AS, Catalytic promiscuity, Multi-component reaction, Naphthopyran derivative

Abstract:

"Amano" lipase AS(lipase from Aspergillus niger), which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.

Key words: “Amano&rdquo, lipase AS, Catalytic promiscuity, Multi-component reaction, Naphthopyran derivative