One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

doi:10.1007/s40242-013-2362-x

高等学校化学研究 ›› 2013, Vol. 29 ›› Issue (4): 710-713.doi: 10.1007/s40242-013-2362-x

One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

JIN Li-li, LEI Yun-tao

College of Sciences, China Pharmaceutical University, Nanjing 210009, P. R. China

收稿日期:2012-09-09 修回日期:2012-11-05 出版日期:2013-08-01 发布日期:2013-07-15
通讯作者: Yun-tao E-mail:Leiyt10@cpu.edu.cn
基金资助:
Supported by the Fundamental Research Funds for the Central Universities, China(No.JKQ2011003).

One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

JIN Li-li, LEI Yun-tao

College of Sciences, China Pharmaceutical University, Nanjing 210009, P. R. China

Received:2012-09-09 Revised:2012-11-05 Online:2013-08-01 Published:2013-07-15
Contact: Yun-tao E-mail:Leiyt10@cpu.edu.cn
Supported by:
Supported by the Fundamental Research Funds for the Central Universities, China(No.JKQ2011003).

摘要/Abstract

摘要：

An effcient synthetic protocol for the β-amino carbonyl compounds was developed via one-pot three-component Mannich reaction of aromatic aldehydes, aromatic amines and cyclohexanone catalyzed by 2-hydroxylpy-ridine under mild reaction conditions. β-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. The effects of different solvents, catalyst amounts and the scope of different substrates on the Mannich reactions were investigated. The plausible reaction mechanism was also discussed.

关键词: 2-Hydroxylpyridine, Catalyze, Mannich reaction, β-Amino carbonyl compound

Abstract:

Key words: 2-Hydroxylpyridine, Catalyze, Mannich reaction, β-Amino carbonyl compound

JIN Li-li, LEI Yun-tao. One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine[J]. 高等学校化学研究, 2013, 29(4): 710-713.

JIN Li-li, LEI Yun-tao. One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine[J]. Chemical Research in Chinese Universities, 2013, 29(4): 710-713.

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One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

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