高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (4): 614-618.
Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(I)
MI Hao-yu1, CUI Lin-lin1, ZHANG Qun-li1, LI Fang2, JIANG Tao2, LIANG Yong-tao1* and WANG En-si1,2*
- 1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China
Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(I)
MI Hao-yu1, CUI Lin-lin1, ZHANG Qun-li1, LI Fang2, JIANG Tao2, LIANG Yong-tao1* and WANG En-si1,2*
- 1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China
摘要： A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes. The structures were confirmed by means of 1H NMR, 13C NMR, IR and MS. Most of the compounds display moderate to potent inhibitory activity. Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.