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高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (6): 650-653.

• Articles • 上一篇    下一篇

Determination of Vitamin B1 in Pharmaceutical Preparations by Flow-injection Analysis with Biamperometric Detection

LI Li-jun1, CHENG Hao1,2, ZHAO Chuan2, HU Xiao-ge2   

  1. 1. Department of Biological and Chemical Engineering, Guangxi University of Technology,Liuzhou 545006, P. R. China;
    2. Institute of Analytical Science, Northwest University, Xi'an 710069, P. R. China
  • 收稿日期:2005-03-07 出版日期:2005-11-23 发布日期:2011-08-06
  • 基金资助:

    Supported by Guangxi Young Science Foundation (No.0135003) and Middle Young Science Scholar Leader Foundation of Guangxi Universities

Determination of Vitamin B1 in Pharmaceutical Preparations by Flow-injection Analysis with Biamperometric Detection

LI Li-jun1, CHENG Hao1,2, ZHAO Chuan2, HU Xiao-ge2   

  1. 1. Department of Biological and Chemical Engineering, Guangxi University of Technology,Liuzhou 545006, P. R. China;
    2. Institute of Analytical Science, Northwest University, Xi'an 710069, P. R. China
  • Received:2005-03-07 Online:2005-11-23 Published:2011-08-06
  • Supported by:

    Supported by Guangxi Young Science Foundation (No.0135003) and Middle Young Science Scholar Leader Foundation of Guangxi Universities

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被引次数

2

摘要： A new electrochemical method for the on-line determination of vitamin B1 is presented.Based on dead-stop endpoint biamperometry by using two platinum foil electrodes with an applied potential difference of 150 mV, vitamin B1 can be oxidized by hexacyanoferrate (Ⅲ) in a sodium hydroxide medium via a reversible indicating couple Fe(CN)64-/Fe(CN)63-.The cell current is linear with the concentration of vitamin B1 in the concentration range of 4.0×10-6—1.0 × 10-3 mol/L with a detection limit of 8.0×10-7 mol/L(0.27 μg/mL).Most familiar excipients,ions and vitamins do not interfere with the determination of vitamin B1.The method displays the advantages of simplicity, high efficiency(180 samples/h), and high selectivity, and is suitable for the determination of vitamin B1 in pharmaceutical preparations.

关键词: Pharmaceutical analysis, Biamperometry, Vitamin B1, Flow-injection analysis

Abstract: A new electrochemical method for the on-line determination of vitamin B1 is presented.Based on dead-stop endpoint biamperometry by using two platinum foil electrodes with an applied potential difference of 150 mV, vitamin B1 can be oxidized by hexacyanoferrate (Ⅲ) in a sodium hydroxide medium via a reversible indicating couple Fe(CN)64-/Fe(CN)63-.The cell current is linear with the concentration of vitamin B1 in the concentration range of 4.0×10-6—1.0 × 10-3 mol/L with a detection limit of 8.0×10-7 mol/L(0.27 μg/mL).Most familiar excipients,ions and vitamins do not interfere with the determination of vitamin B1.The method displays the advantages of simplicity, high efficiency(180 samples/h), and high selectivity, and is suitable for the determination of vitamin B1 in pharmaceutical preparations.

Key words: Pharmaceutical analysis, Biamperometry, Vitamin B1, Flow-injection analysis