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高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (2): 127-130.

• Articles •    下一篇

A Novel 5-Fluorouracil Salt of 12-Silicatungstic Acid: Synthesis, Structure Characterization and Antitumor Activity

LI Juan, WU Xin-yu, LI Jing, WANG Hong-fang, QI Yan-fei, YU Xi-he, SUN Zhi-wei, WANG En-bo   

  1. 1. Department of Hygienic Chemistry, School of Public Health, Jilin University, Changchun 130021, P. R. China;
    2. Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China
  • 收稿日期:2004-10-20 出版日期:2005-03-24 发布日期:2011-07-27
  • 基金资助:

    Spported by the National Natural Science Foundation of China(No.20171010).

A Novel 5-Fluorouracil Salt of 12-Silicatungstic Acid: Synthesis, Structure Characterization and Antitumor Activity

LI Juan1, WU Xin-yu1, LI Jing1, WANG Hong-fang1, QI Yan-fei2, YU Xi-he1, SUN Zhi-wei1, WANG En-bo2   

  1. 1. Department of Hygienic Chemistry, School of Public Health, Jilin University, Changchun 130021, P. R. China;
    2. Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China
  • Received:2004-10-20 Online:2005-03-24 Published:2011-07-27
  • Supported by:

    Spported by the National Natural Science Foundation of China(No.20171010).

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被引次数

5

摘要： A novel 5-fluorouracil salt of 12-silicatungstic acid was synthesized and characterized by means of elemental analysis, IR, 1H NMR and 183W NMR spectra.The antitumor activity and toxicity of the complex have been evaluated both in vitro and in vivo.

Abstract: A novel 5-fluorouracil salt of 12-silicatungstic acid was synthesized and characterized by means of elemental analysis, IR, 1H NMR and 183W NMR spectra.The antitumor activity and toxicity of the complex have been evaluated both in vitro and in vivo.

Key words: Polyoxotungstate, 5-Fu, Antitumor activity, Toxicity