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高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (S1): 24-25.

• Articles • 上一篇    下一篇

Production of 7-ADCA,GCLE and Cephalosporin

GUAN Zuo-Wu, MA Zhuang, LU Kuan-Ke, LI Lian-Tao, LIU Shu-Jing, WANG Wen-Zhong   

  1. The Research & Development Center of Beijing-Kych β-lactam Antibiotics, Beijing University, Beijing 100083
  • 出版日期:2001-12-31 发布日期:2016-03-14

Production of 7-ADCA,GCLE and Cephalosporin

GUAN Zuo-Wu, MA Zhuang, LU Kuan-Ke, LI Lian-Tao, LIU Shu-Jing, WANG Wen-Zhong   

  1. The Research & Development Center of Beijing-Kych β-lactam Antibiotics, Beijing University, Beijing 100083
  • Online:2001-12-31 Published:2016-03-14

PDF (PC)

被引次数

2

摘要：

The production of 7-aininodeaceloxy cephalosporanic acid(7-ADCA),4'-nitrobenzyl-3-bromomethy 1-3-cephem-4-carboxylate(GCLE) and their analo-gues from penicillin G.K.is an important national project for the new drug development.In this project 7-ADC A is produced by oxidation,ring expansion and enzyme splitting reaction of penicillin G,K(Scheme 1).

Abstract:

The production of 7-aininodeaceloxy cephalosporanic acid(7-ADCA),4'-nitrobenzyl-3-bromomethy 1-3-cephem-4-carboxylate(GCLE) and their analo-gues from penicillin G.K.is an important national project for the new drug development.In this project 7-ADC A is produced by oxidation,ring expansion and enzyme splitting reaction of penicillin G,K(Scheme 1).