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高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (S1): 176-177.

• Articles • 上一篇    下一篇

Design,Synthesis,Anticancer Pharmacology of Actinomycin D Analogues:5,5'-MeSer2-ActD and 5,5,-MeAla2-ActD

NI Jing-Man1, YANG Xiao-Wu2, JIA Zheng-Ping2, PAN Xing-Fu3, WANG Rui2   

  1. 1. Department of Pharmacy, Lanzhou Medical College, Lanzhou 730000;
    2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000;
    3. Department of Chemistry. College of Chemistry and Chemical Engineering Lanzhou University, Lanzhou 730000
  • 出版日期:2001-12-31 发布日期:2016-03-14
  • 基金资助:

    This work was supported by the Natural Science Foundation of Gansu Province(ZS001-A23-057-Y)

Design,Synthesis,Anticancer Pharmacology of Actinomycin D Analogues:5,5'-MeSer2-ActD and 5,5,-MeAla2-ActD

NI Jing-Man1, YANG Xiao-Wu2, JIA Zheng-Ping2, PAN Xing-Fu3, WANG Rui2   

  1. 1. Department of Pharmacy, Lanzhou Medical College, Lanzhou 730000;
    2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000;
    3. Department of Chemistry. College of Chemistry and Chemical Engineering Lanzhou University, Lanzhou 730000
  • Online:2001-12-31 Published:2016-03-14
  • Supported by:

    This work was supported by the Natural Science Foundation of Gansu Province(ZS001-A23-057-Y)

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摘要：

Actinomycin D(ActD,Figure 1.),containing a planar phenoxazonc ring and two cyclic pentapeptides,is one of the most intensely studied anticancer drugs and currently used to treat highly malignant tumors,such as Wilms' tumor and gestational choriocarcinoma.Although ActD possesses high antitumor activities,its clinical usefulness is limited by its extreme cytotoxicity.

Abstract:

Actinomycin D(ActD,Figure 1.),containing a planar phenoxazonc ring and two cyclic pentapeptides,is one of the most intensely studied anticancer drugs and currently used to treat highly malignant tumors,such as Wilms' tumor and gestational choriocarcinoma.Although ActD possesses high antitumor activities,its clinical usefulness is limited by its extreme cytotoxicity.