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高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (S1): 134-135.

• Articles • 上一篇    下一篇

The Practical Asymmetric Syntheses of Key Chiral Intermediates of Chiral Drug from Four-Carbon Chiral Pool

MI Ai-Qiao, LIN Wen-Qin, HE Zhe, JIN Yi, JIANG Yao-Zhong   

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
  • 出版日期:2001-12-31 发布日期:2016-03-14
  • 通讯作者: MI Ai-Qiao,Fax:+285229250,E-mail:ulas@cioc.ac.cn E-mail:ulas@cioc.ac.cn

The Practical Asymmetric Syntheses of Key Chiral Intermediates of Chiral Drug from Four-Carbon Chiral Pool

MI Ai-Qiao, LIN Wen-Qin, HE Zhe, JIN Yi, JIANG Yao-Zhong   

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
  • Online:2001-12-31 Published:2016-03-14
  • Contact: MI Ai-Qiao,Fax:+285229250,E-mail:ulas@cioc.ac.cn E-mail:ulas@cioc.ac.cn

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摘要：

(S)-or(R)-2-Amino-4-phenylbutyric acid and(S)- or(R)-2-hydroxy-4-phenylbutyric acid and their ethyl esters are key chiral intermediates for the preparation of angiotensin converting enzyme inhibitors(ACEI) and other chiral drugs.

Abstract:

(S)-or(R)-2-Amino-4-phenylbutyric acid and(S)- or(R)-2-hydroxy-4-phenylbutyric acid and their ethyl esters are key chiral intermediates for the preparation of angiotensin converting enzyme inhibitors(ACEI) and other chiral drugs.