高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (S1): 111-111.
Unique Cyclin-Dependent Kinase(CDK) Inhibitors at the ATP-site
LI Lin, CHONG Wesley K M., DUVADIE Rohit K, CHU Shao Song, YANG Y. Michelle, NONOMIYA Jim, TUCKER Kadthleen D., KNIGHTON Daniel R., FERRE RoseAnn, LUNDGREN Karen, ESCOBAR Jorge, MINNICK Sharon price, HUBER Andrea, KOUDRIAKOVA T atiana, ARRUDA Jeannie, SISSON Wes, AUST Robert M., VERKHIVKER Gennady M., SCHAFFER Lana, ROSE Peter w, and LEWIS Cristina T.
Unique Cyclin-Dependent Kinase(CDK) Inhibitors at the ATP-site
LI Lin, CHONG Wesley K M., DUVADIE Rohit K, CHU Shao Song, YANG Y. Michelle, NONOMIYA Jim, TUCKER Kadthleen D., KNIGHTON Daniel R., FERRE RoseAnn, LUNDGREN Karen, ESCOBAR Jorge, MINNICK Sharon price, HUBER Andrea, KOUDRIAKOVA T atiana, ARRUDA Jeannie, SISSON Wes, AUST Robert M., VERKHIVKER Gennady M., SCHAFFER Lana, ROSE Peter w, and LEWIS Cristina T.
摘要：
Control of the cell cycle could be applicable in new approaches for cancer chemotherapy.The cyclin-dependent kinases(CDK's) and their corresponding complexes with cyclins are regulatory enzymes for which we have discovered a novel small molecule series of inhibitors,with potencies in the nanomolar range and good selectivity for the CDK's versus other kinases.