Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

doi:10.1007/s40242-024-4032-6

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (2): 255-267.doi: 10.1007/s40242-024-4032-6

Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

NAN Hexin, CAI Ming, KUANG Shi, NIE Zhou

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China

收稿日期:2024-02-15 修回日期:2024-03-13 出版日期:2024-04-01 发布日期:2024-03-27
通讯作者: NIE Zhou niezhou@hnu.edu.cn
基金资助:
This work was supported by the National Key Research and Development Program of China (Nos. 2021YFA0910100, 2020YFA0907500) and the National Natural Science Foundation of China (Nos. 22034002, 92253304).

Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

NAN Hexin, CAI Ming, KUANG Shi, NIE Zhou

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China

Received:2024-02-15 Revised:2024-03-13 Online:2024-04-01 Published:2024-03-27
Contact: NIE Zhou niezhou@hnu.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China (Nos. 2021YFA0910100, 2020YFA0907500) and the National Natural Science Foundation of China (Nos. 22034002, 92253304).

摘要/Abstract

摘要： The cell membrane is a critical barrier for cellular homeostasis, integral to signaling and intercellular communication, and vital for understanding cellular functions and disease mechanisms. Investigating its microenvironment is crucial for uncovering the molecular basis of physiological and pathological processes associated with the cell membrane, driving the development of bioanalytical toolkits capable of dynamically monitoring the cell surface microenvironment. With the continuous advancement of functional nucleic acids and dynamic DNA nanotechnology, DNA nanodevices with controllable nanosized geometry, specific molecular recognition, and selective membrane-localization properties offer a versatile platform for probing the cell membrane microenvironment. In this review, we summarize the current biosensing and membrane-anchoring mechanisms of DNA nanodevices and highlight their use in studying key cell membrane events, including membrane lipid dynamics, transmembrane transport, receptor dimerization, and signal transduction. Furthermore, we discuss the challenges and potential future applications of DNA nanodevices in advancing cell membrane biology research and biomedical applications.

关键词: DNA nanodevice, Cell membrane, Cellular micro-environment, Monitoring

Abstract: The cell membrane is a critical barrier for cellular homeostasis, integral to signaling and intercellular communication, and vital for understanding cellular functions and disease mechanisms. Investigating its microenvironment is crucial for uncovering the molecular basis of physiological and pathological processes associated with the cell membrane, driving the development of bioanalytical toolkits capable of dynamically monitoring the cell surface microenvironment. With the continuous advancement of functional nucleic acids and dynamic DNA nanotechnology, DNA nanodevices with controllable nanosized geometry, specific molecular recognition, and selective membrane-localization properties offer a versatile platform for probing the cell membrane microenvironment. In this review, we summarize the current biosensing and membrane-anchoring mechanisms of DNA nanodevices and highlight their use in studying key cell membrane events, including membrane lipid dynamics, transmembrane transport, receptor dimerization, and signal transduction. Furthermore, we discuss the challenges and potential future applications of DNA nanodevices in advancing cell membrane biology research and biomedical applications.

Key words: DNA nanodevice, Cell membrane, Cellular micro-environment, Monitoring

NAN Hexin, CAI Ming, KUANG Shi, NIE Zhou. Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices[J]. 高等学校化学研究, 2024, 40(2): 255-267.

NAN Hexin, CAI Ming, KUANG Shi, NIE Zhou. Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices[J]. Chemical Research in Chinese Universities, 2024, 40(2): 255-267.

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Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

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