Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation

doi:10.1007/s40242-019-8399-8

高等学校化学研究 ›› 2019, Vol. 35 ›› Issue (4): 621-626.doi: 10.1007/s40242-019-8399-8

Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation

GUO Lianghua, XU Mei, JIAN Yong, LIU Sheng, PAN Weidong, DUAN Lian

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P. R. China

收稿日期:2018-12-21 修回日期:2019-04-02 出版日期:2019-08-01 发布日期:2019-08-01
通讯作者: PAN Weidong, DUAN Lian E-mail:wdpan@163.com;duanlianlab@126.com
基金资助:
Supported by the National Natural Science Foundation of China(No.21762014) and the Science Foundation of Guizhou Province, China(No.[2015] 2107).

Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation

GUO Lianghua, XU Mei, JIAN Yong, LIU Sheng, PAN Weidong, DUAN Lian

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P. R. China

Received:2018-12-21 Revised:2019-04-02 Online:2019-08-01 Published:2019-08-01
Contact: PAN Weidong, DUAN Lian E-mail:wdpan@163.com;duanlianlab@126.com
Supported by:
Supported by the National Natural Science Foundation of China(No.21762014) and the Science Foundation of Guizhou Province, China(No.[2015] 2107).

摘要/Abstract

摘要： A one-pot and efficient three-component reaction of indoles, acrylates and maleimides for the synthesis of pyrrolo[3,4-a]carbazole-1,3-dione derivatives was developed. Three C-C bonds and one ring were created in a single step via an indole-to-carbazole transformation triggered by Pd(Ⅱ)-catalyzed direct C3-alkenylation of indoles.

关键词: Carbazole, One-pot, Tandem reaction, Three-component reaction, Indole-to-carbazole

Abstract: A one-pot and efficient three-component reaction of indoles, acrylates and maleimides for the synthesis of pyrrolo[3,4-a]carbazole-1,3-dione derivatives was developed. Three C-C bonds and one ring were created in a single step via an indole-to-carbazole transformation triggered by Pd(Ⅱ)-catalyzed direct C3-alkenylation of indoles.

Key words: Carbazole, One-pot, Tandem reaction, Three-component reaction, Indole-to-carbazole

GUO Lianghua, XU Mei, JIAN Yong, LIU Sheng, PAN Weidong, DUAN Lian. Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation[J]. 高等学校化学研究, 2019, 35(4): 621-626.

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Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation

Tandem Approach to Functionalized Pyrrolo[3,4-a]carbazole-1,3-diones via a Pd-catalyzed Indole-to-carbazole Transformation

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