Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components

doi:10.1007/s40242-018-8250-7

高等学校化学研究 ›› 2019, Vol. 35 ›› Issue (1): 65-70.doi: 10.1007/s40242-018-8250-7

Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components

WU Zhimin^1,2, DING Haiou^1,2, YANG Chang¹, GUO Shujuan¹, DAI Xingxing^1,2, SHI Xinyuan^1,2

1. Traditional Chinese Medicine Institute, Beijing University of Chinese Medicine, Beijing 100029, P. R. China;
2. Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing 100029, P. R. China

收稿日期:2018-08-06 修回日期:2018-11-06 出版日期:2019-02-01 发布日期:2018-11-12
通讯作者: SHI Xinyuan E-mail:xyshi@126.com
基金资助:
Supported by the Natural Science Foundation of Beijing, China(No.7162122).

Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components

WU Zhimin^1,2, DING Haiou^1,2, YANG Chang¹, GUO Shujuan¹, DAI Xingxing^1,2, SHI Xinyuan^1,2

1. Traditional Chinese Medicine Institute, Beijing University of Chinese Medicine, Beijing 100029, P. R. China;
2. Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing 100029, P. R. China

Received:2018-08-06 Revised:2018-11-06 Online:2019-02-01 Published:2018-11-12
Contact: SHI Xinyuan E-mail:xyshi@126.com
Supported by:
Supported by the Natural Science Foundation of Beijing, China(No.7162122).

摘要/Abstract

摘要： In this study, a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components. Two factors were mainly considered, including the XlogP value of drug components and the sugar chain length of platycodin. As a result, it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin, and it was different between the drug's own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect.

关键词: Platycodin, Dissipative particle dynamics, Solubilization enhancing effect, XlogP

Abstract: In this study, a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components. Two factors were mainly considered, including the XlogP value of drug components and the sugar chain length of platycodin. As a result, it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin, and it was different between the drug's own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect.

Key words: Platycodin, Dissipative particle dynamics, Solubilization enhancing effect, XlogP

WU Zhimin, DING Haiou, YANG Chang, GUO Shujuan, DAI Xingxing, SHI Xinyuan. Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components[J]. 高等学校化学研究, 2019, 35(1): 65-70.

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Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components

Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components

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