One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

doi:10.1007/s40242-018-8148-4

高等学校化学研究 ›› 2018, Vol. 34 ›› Issue (6): 918-922.doi: 10.1007/s40242-018-8148-4

One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

JIANG Zhenlei¹, LIU Jie^1,2, ZHOU Fan¹, ZHANG Jianrun¹, LIU Zhijun¹, ZHANG Chao¹, CHEN Heru^1,3

1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China;
2. Department of Allergy, the Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, P. R. China;
3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, P. R. China

收稿日期:2018-05-07 出版日期:2018-12-01 发布日期:2018-08-23
通讯作者: CHEN Heru E-mail:thrchen@jnu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.81172982) and the Natural Science Foundation of Guangdong Province, China(No.2015A030311012).

One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

JIANG Zhenlei¹, LIU Jie^1,2, ZHOU Fan¹, ZHANG Jianrun¹, LIU Zhijun¹, ZHANG Chao¹, CHEN Heru^1,3

1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China;
2. Department of Allergy, the Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, P. R. China;
3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, P. R. China

Received:2018-05-07 Online:2018-12-01 Published:2018-08-23
Contact: CHEN Heru E-mail:thrchen@jnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.81172982) and the Natural Science Foundation of Guangdong Province, China(No.2015A030311012).

摘要/Abstract

摘要： An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid(DMXAA) was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.

关键词: 5,6-Dimethylxanthenone-4-acetic acid, Xanthone, Microwave irradiation, Anti-cancer

Abstract: An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid(DMXAA) was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.

Key words: 5,6-Dimethylxanthenone-4-acetic acid, Xanthone, Microwave irradiation, Anti-cancer

JIANG Zhenlei, LIU Jie, ZHOU Fan, ZHANG Jianrun, LIU Zhijun, ZHANG Chao, CHEN Heru. One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA[J]. 高等学校化学研究, 2018, 34(6): 918-922.

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One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

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