高等学校化学研究 ›› 2017, Vol. 33 ›› Issue (3): 327-332.doi: 10.1007/s40242-017-6496-0
Preparation of CdTe Nanocrystals Doped Fluorescent Silica Spheres by Sol-gel Method and Their Surface Modification via Thiol-ene Chemistry
LIU Yan1,2, YU Dongdong3, ZHU Wei2, BAI Xiao2, SHEN Qihui1,2, LIU Xiaoyang2, ZHOU Jianguang4
- 1. Department of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China;
2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
3. Hospital of Zhejiang University, Hangzhou 310027, P. R. China;
4. State Key Laboratory of Industrial Control Technology, Research Center for Analytical Instrumentation, College of Control Science and Engineering, Zhejiang University, Hangzhou 310058, P. R. China
Preparation of CdTe Nanocrystals Doped Fluorescent Silica Spheres by Sol-gel Method and Their Surface Modification via Thiol-ene Chemistry
LIU Yan1,2, YU Dongdong3, ZHU Wei2, BAI Xiao2, SHEN Qihui1,2, LIU Xiaoyang2, ZHOU Jianguang4
- 1. Department of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China;
2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
3. Hospital of Zhejiang University, Hangzhou 310027, P. R. China;
4. State Key Laboratory of Industrial Control Technology, Research Center for Analytical Instrumentation, College of Control Science and Engineering, Zhejiang University, Hangzhou 310058, P. R. China
摘要：
A facile one-step sol-gel method was used to prepare CdTe nanocrystals(NCs) doped silica microspheres with luxuriant thiol group on their surface using 3-mercaptopropyl trimethoxysilane(MPTMS) as organosilane in the aqueous solution. As the ligand and organosilane, MPTMS ensured the doping efficiency of CdTe NCs by ligand exchange and a large thiol group exposed to the solution to activate the surface of silica microspheres. The remodeled sol-gel process was performed at a lower temperature, which protected the thiol groups from degradation. Meanwhile, the particle size and size distribution can be controlled by varying synthesis conditions, such as the stirring rate and the reaction temperature. This user-friendly method provides a platform for immobilization of chemical groups such as carboxyl for combination of bioactive and diagnostic molecules at the surface of CdTe NCs doped silica microspheres through thiol-ene chemistry for high-throughput microarrays.