Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

doi:10.1007/s40242-014-4039-5

高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (6): 959-964.doi: 10.1007/s40242-014-4039-5

Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

WANG Li^1,2, WANG Liping³, XU Tianshu³, GUO Changrun³, LIU Chuanzhi⁴, ZHANG Hao⁵, LI Jing⁵, LIANG Zhiqing¹

1. Department of Obstetrics & Gynecology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, P. R. China;
2. The 208 Hospital of PLA, Changchun 130062, P. R. China;
3. College of Life Science, Jilin University, Changchun 130012, P. R. China;
4. College of Life Science, Changchun University of Science and Technology, Changchun 130012, P. R. China;
5. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China

收稿日期:2014-01-27 修回日期:2014-08-04 出版日期:2014-12-01 发布日期:2014-11-20
通讯作者: LIANG Zhiqing E-mail:zhi.lzliang@gmail.com
基金资助:
Supported by the Natural Science Foundation of Jilin Province, China(Nos.201015171, YYZX201150-2, 201205017, 12SF23).

Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

WANG Li^1,2, WANG Liping³, XU Tianshu³, GUO Changrun³, LIU Chuanzhi⁴, ZHANG Hao⁵, LI Jing⁵, LIANG Zhiqing¹

1. Department of Obstetrics & Gynecology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, P. R. China;
2. The 208 Hospital of PLA, Changchun 130062, P. R. China;
3. College of Life Science, Jilin University, Changchun 130012, P. R. China;
4. College of Life Science, Changchun University of Science and Technology, Changchun 130012, P. R. China;
5. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China

Received:2014-01-27 Revised:2014-08-04 Online:2014-12-01 Published:2014-11-20
Contact: LIANG Zhiqing E-mail:zhi.lzliang@gmail.com
Supported by:
Supported by the Natural Science Foundation of Jilin Province, China(Nos.201015171, YYZX201150-2, 201205017, 12SF23).

摘要/Abstract

摘要：

In this work, we synthesized the polypyrrole(PPy) modified gold nanoparticles and demonstrated their negligible cytotoxicity in vitro. These nanoparticles have also been demonstrated to efficiently ablate different kinds of tumor cells in vitro under the irradiation of the near-infrared laser. When the PPy modified gold nanoparticles were conjugated with the tumor-targeted molecule of 15P(sequence: SHSWHWLPNLRHYAS), these conjugates displayed hyperthermia effects on the human ovarian cancer cell line SK-OV-3 cells in vitro under the irradiation of near-infrared laser, showing great tumor-targeted treatment efficiency. To determine the potential hyperthermia effect of PPy modified gold nanoparticles or 15P-conjugate on tumor cells in vivo, the SK-OV-3 cells were used to induce the subcutaneous tumor-bearing nude mice. The significant inhibition effects of near-infrared laser mediated PPy modified gold nanoparticles or 15P-conjugate on the tumor growth were observed. These composite results suggest that the 15P-conjugated PPy modified gold nanoparticles exhibit great biocompatibility, particularly tumor-targeted effect and the effective photothermal ablation of tumor cells, which warrants the potential therapeutic value of this conjugate for further application to the in vivo localized tumor therapy.

关键词: Gold nanorod, Photothermal therapy, SK-OV-3 cell, Tumor cell

Abstract:

Key words: Gold nanorod, Photothermal therapy, SK-OV-3 cell, Tumor cell

WANG Li, WANG Liping, XU Tianshu, GUO Changrun, LIU Chuanzhi, ZHANG Hao, LI Jing, LIANG Zhiqing. Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer[J]. 高等学校化学研究, 2014, 30(6): 959-964.

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Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

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