Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins

doi:10.1007/s40242-013-3107-6

高等学校化学研究 ›› 2013, Vol. 29 ›› Issue (6): 1125-1128.doi: 10.1007/s40242-013-3107-6

Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins

LIU Zhi-hui¹, LI De-jun², JIANG Dan³, XIAO Chuan², SONG Zhi-guang², JIN Ying-hua³

1. Department of Prosthodontics, School of Stomatology, Changchun 130021, P. R. China;
2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130012, P. R. China

收稿日期:2013-03-11 修回日期:2013-04-19 发布日期:2013-11-22
通讯作者: SONG Zhi-guang E-mail:szg@jlu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(No.90813003).

Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins

LIU Zhi-hui¹, LI De-jun², JIANG Dan³, XIAO Chuan², SONG Zhi-guang², JIN Ying-hua³

1. Department of Prosthodontics, School of Stomatology, Changchun 130021, P. R. China;
2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130012, P. R. China

Received:2013-03-11 Revised:2013-04-19 Published:2013-11-22
Contact: SONG Zhi-guang E-mail:szg@jlu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.90813003).

摘要/Abstract

摘要：

A new series of 7-substituted 3-arylcoumarins was designed, synthesized and evaluated as novel antitumor agents in vitro. It was found that several compounds of them exhibit activity in vitro against SK-HEP-1(hepatocellu-lar carcinoma), HepG2(hepatocellular carcinoma) and SGC7901(gastric carcinoma) cell lines to some extent. Moreover, compounds 5a, 5b, 6a and 6b have better activity against HeLa(cervical carcinoma) cell and their half maximal inhibitory concentration(IC₅₀) values are less than 10 μmol/L.

关键词: 3-Arylcoumarin, Antitumor activity, Structure modification

Abstract:

Key words: 3-Arylcoumarin, Antitumor activity, Structure modification

LIU Zhi-hui, LI De-jun, JIANG Dan, XIAO Chuan, SONG Zhi-guang, JIN Ying-hua. Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins[J]. 高等学校化学研究, 2013, 29(6): 1125-1128.

LIU Zhi-hui, LI De-jun, JIANG Dan, XIAO Chuan, SONG Zhi-guang, JIN Ying-hua. Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins[J]. Chemical Research in Chinese Universities, 2013, 29(6): 1125-1128.

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Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins

Design, Synthesis and Antitumor Activity in vitro of a Series of 3-Arylcoumarins

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