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Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes XU Dejun, HE Liu, ZENG Fudong, LIU Bo, MA Jinli, HAN Dongmei, YANG Qingbiao, DU Jianshi Chemical Research in Chinese Universities    2024, 40 (6): 1050-1059.   DOI: 10.1007/s40242-024-3262-y Abstract （267）            Knowledge map    Save Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 ℃ for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I2 to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds. Reference | Related Articles | Metrics

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Reproductive Toxicities of Tetradecyltrimethylammonium Chloride and Tetradecyltrimethylammonium Bromide on Caenorhabditis elegans over Four Consecutive Generations ZHANG Jing, DING Ruoqi, YU Zhenyang Chemical Research in Chinese Universities    2024, 40 (6): 1060-1067.   DOI: 10.1007/s40242-024-3266-7 Abstract （284）            Knowledge map    Save Quaternary ammonium compounds (QACs) become emerging pollutants and their toxicities earn increasing attention. So far, their reproductive toxicities were poorly investigated, and their effects over generations were even less explored. In the present study, reproductive toxicities of two QACs, i.e., tetradecyltrimethylammonium chloride (TTAC) and tetradecyltrimethylammonium bromide (TTAB) were studied on Caenorhabditis elegans with a consecutive exposure over four generations (from F1 to F4). The effects of TTAC on total and initial reproduction showed stimulation and inhibition, which oscillated from F1 to F4. The effects of TTAB on the total reproduction commonly showed stimulation over generations with the greatest stimulation in F2, and it inhibited the initial reproduction but stimulated the reproduction duration. Further exploration demonstrated that TTAC and TTAB significantly disturbed the levels of spermatocyte protein 8 (SPE8), sperm transmembrane protein 9 (SPE9), vitellogenin (Vg), major sperm protein (MSP) and ephrin receptor protein tyrosine kinase (VAB-1) and the expressions of vab-1, ceh-18, set-2, met-2 and mes-4. Such disturbances demonstrated that both QACs impacted the reproductive processes via oocyte meiosis, gonadal support and germline development. Notably, the effects of TTAC and TTAB in parents were connected with those in the offspring, which highlighted the roles of reproduction in connecting generations. In addition, different effects between TTAC and TTAB demonstrated the anionic influences on the QACs’ toxicities. Reference | Related Articles | Metrics

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Nano-crystallites Imine-based Copper(II) Complexes as Mimetics for Copper Oxidase Proteins: Synthesis, Characterization, DFT and Oxidase Mimicking Activity ALHADHRAMI Abdulrahman, RAMADAN Abd El-Motaleb, FATHY Ahmed Chemical Research in Chinese Universities    2024, 40 (6): 1068-1081.   DOI: 10.1007/s40242-024-3273-8 Abstract （292）            Knowledge map    Save Three tridentate imine ligands containing N2S donors were synthesized via Schiff condensation between derivatives of both amino triazine and 2-carbonyl pyridine. The reaction of these ligands with CuCl2 in a molar ratio of 1:1 provides three Cu(II) complexes with the general formula [CuLn·Cl2]. Analytical, electrical, magnetic, and spectroscopic studies were used to assign the molecular formulae of these metallic chelates. Density function theory (DFT) calculations confirmed the structural analysis results obtained from spectroscopic studies. The various characterization techniques used demonstrated the penta-coordinated slightly distorted square pyramidal structure for the present Cu(II) complexes 1, 2, and 3. Measurements of cyclic voltammetry were done in methanol to define the electrochemical behavior of the current Cu(II) complexes. The biomimetics of catechol oxidase (C.O.) and phenoxazinone synthase (PHS) have been studied in the aerobic oxidation of some phenolic substrates, such as 3,5-di-tert-butylcatechol (3,5-DTBCH2) and ortho-aminophenol (o-APH3). The three candidate oxidase mimetics showed promising activity in the order 3 > 1 > 2. The catalytic activity related to the structural properties of existing oxidase mimetics was discussed. The driving force (-ΔG°) controlling the redox reactions of the present biomolecules was calculated from the redox data of Cu(II) complexes 1, 2, and 3. The potential catalytic reaction pathway for the oxidation of the studied phenolic substrates was discussed. Reference | Related Articles | Metrics

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CNTs-promoted Co-Cu Catalyst for Efficient Synthesis of Cinnamyl Alcohol from Hydrogenation of Cinnamaldehyde DONG Xin, LIU Cheng, ZHOU Zhaohui Chemical Research in Chinese Universities    2024, 40 (6): 1082-1087.   DOI: 10.1007/s40242-024-4007-7 Abstract （276）            Knowledge map    Save With types of in-house-synthesized multi-walled carbon nanotubes (CNTs), highly active CNT-promoted Co-Cu catalysts, symbolized as CoiCuj-x%CNTs (mass fraction) were prepared by the co-precipitation method from nitrate salts of the corresponding metallic components. Their catalytic performances for the cinnamyl alcohol synthesis from the hydrogenation of cinnamaldehyde were studied and compared with the corresponding CNT-free coprecipitated catalyst of CoiCuj mixed oxide. It was shown that the appropriate incorporation of a minor amount of the CNTs into CoiCuj oxide could significantly increase the catalytic activity for cinnamyl alcohol synthesis. Under the pressure of 5.0 MPa, the highest yield of cinnamyl alcohol reaches 94.4% with selectivity of 98.7% for the catalyst Co2-Cu1-10.0%CNTs. The addition of an appropriate amount of CNT can promote the highly dispersed catalyst and promote the recovery of the catalyst. The results show that carbon nanotube is an excellent accelerator, and its properties for unique hydrogen absorption play important roles in promoting the synthesis of cinnamyl alcohol. Reference | Related Articles | Metrics