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    Aggregation-induced Emission Probe for Fluorescence/ Photoacoustic Dual-modality Imaging and Photodynamic/Photothermal Treatment
    CHEN Peiyu, ZHANG Guoyang, LI Jiguang, MA Lijun, ZHOU Jiaying, ZHU Mingguang, LI Shuo, WANG Zhuo
    Chemical Research in Chinese Universities    2024, 40 (2): 293-304.   DOI: 10.1007/s40242-024-3256-9
    Abstract16)            Save
    The combination of near-infrared (NIR) fluorescence imaging (FLI) and photoacoustic imaging (PAI) can effectively compensate for each other's inherent limitations, which can provide reliable and rich information on tumor biology. Therefore, the development of FL/PA dual-modality imaging probes is beneficial for achieving precision cancer diagnosis and treatment. Herein, we designed an efficient phototherapy agent methoxy bithiophene indene (OTIC), which was based on aggregation-induced emission (AIE) active fluorophores. To improve the water dispersion and enrichment of OTIC at the tumor site, OTIC nanoparticles (OTIC NPs) were prepared by a nanoprecipitation method. The balance between radiation and non-radiation energy dissipation was regulated by the strong donor-acceptor interaction and intramolecular motion. So OTIC NPs exhibited bright NIR fluorescence, photoacoustic signals, efficient generation of reactive oxygen species, and high photothermal conversion efficiency under NIR irradiation. Accurate imaging of the tumor and mice sentinel lymph nodes (SLNs) with OTIC NPs was visualized by NIR FL/PA dual-modal imaging. With the comprehensive imaging information provided by OTIC NPs in vivo, tumors were ablated under laser irradiation, which greatly improved the therapeutic efficacy. OTIC NPs would be possible to realize the precise guidance of FL/PA imaging for tumor treatment in the future clinical application.
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    Colorimetric and Photothermal Dual-modal Visual Detection of Iodide Ion Based on G-Quadruplex-Hemin Cascade Signal Amplification
    CHEN Yanyue, LIU Jiali, LIU Jiawen, HU Rong, YANG Yunhui, ZHANG Xiaobing
    Chemical Research in Chinese Universities    2024, 40 (2): 305-310.   DOI: 10.1007/s40242-024-3283-6
    Abstract17)            Save
    The insufficient internal resorption of iodide ions (I) leads to thyroid disorders, such as goiter, hypothyroidism, and cretinism in adults. In this paper, a portable point-of-care testing (POCT) platform was developed for the dual-modal analysis of I, seamlessly integrating both colorimetric and photothermal thermometer techniques. The quantification of results was achieved using a standard thermometer or smartphone. G-Quadruplex/Hemin (G4/Hemin) is the DNAzyme with peroxidase-like activity. The catalytic efficacy of G-quadruplex structures can be enhanced with the help of I, manifesting as multicolor transitions from colorless to green and then blue, and accompanied by the increase of temperature, which can be used for the quantitative detection of I. Additionally, digital analysis according to the three-color channels (R/G/B) by a cellphone eliminated the requirement for intricate instruments. This dual-modal method for portable I determination is cost-effectiveness, simplicity, remarkable sensitivity (0.5 nmol/L) and selectivity. Besides, it was applied to determining the concentration of I in spiked serum samples.
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    Seedless Synthesis of Gold Nanorods with 5—10 nm in Diameters: a Comprehensive Study
    LI Yalan, XIA Yunsheng
    Chemical Research in Chinese Universities    2024, 40 (2): 311-319.   DOI: 10.1007/s40242-024-3289-0
    Abstract24)            Save
    Small gold nanorods (AuNRs), namely AuNRs with less than 10 nm in diameter, possess a high absorption-to-scattering ratio, a large surface area-to-volume ratio, as well as high cellular uptake behaviors. In this study, we systematically investigate seedless synthesis of AuNRs with diameters ranging from 5 nm to 10 nm. It has been found that several experimental conditions, including the chain length of the used cationic surfactants, and the concentrations of ascorbic acid, NaBH4, and AgNO3 can profoundly affect the obtained products. Under optimal conditions, the production yields of the obtained several AuNRs with different diameters can exceed 90% and even reach almost 100%. The conversion of gold precursors to AuNRs was estimated to be 70%—77% as measured by absorption spectroscopy and inductively coupled plasma mass spectrometry.
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    Single Particle Colorimetric Acid Phosphatase Activity Assay with CeO2-modified Gold Nanoparticles
    ZHU Tang Jiayao, YUAN Xiang, MAO Guojiang, WEI Lin, XIAO Lehui
    Chemical Research in Chinese Universities    2024, 40 (2): 320-325.   DOI: 10.1007/s40242-024-4024-6
    Abstract13)            Save
    Acid phosphatase (ACP) is a ubiquitous phosphatase in living organisms. The abnormal variation of ACP is related to various diseases. Herein, we propose a colorimetric method based on CeO2-modified gold core shell nanoparticles (Au@CeO2 NPs) to analyze ACP activity with high sensitivity and specificity. In this design, 2-phospho-L-ascorbic acid trisodium salt (AAP) is dephosphorylated by ACP and produces reductive ascorbic acid (AA), which makes the CeO2 shell decomposition. A remarkable blue shift of localized surface plasmon resonance peak (LSPR, from yellow to green) along with the scattering intensity ratio changes from individual Au@CeO2 NPs are observed. ACP activity can be quantified by calculating the ratio changes of individual Au@CeO2 NPs. This assay reveals limit of detection (LOD) of 0.044 mU/mL and the linear range of 0.05—5.0 mU/mL, which are much lower than most of spectroscopic measurements in bulk solution. Furthermore, the recovery measurements in real samples are satisfactory and the capacity for practical application is demonstrated. As a consequence, Au@CeO2 NPs used in this assay will find new applications for the ultrasensitive detection of enzyme activity.
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Jihong YU
ISSN 1005-9040
CN 22-1183/O6
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