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高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (1): 34-37.

• Articles • 上一篇    下一篇

Enantiomeric Separation of Antidepressant Trimipramine by Capillary Electrophoresis Combined with Electrochemiluminescence Detection in Aqueous-organic Media

YU Cai-xia1,2, YUAN Bai-qing1 and YOU Tian-yan1*   

  1. 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;
    2. Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China
  • 收稿日期:2010-02-09 修回日期:2010-04-28 出版日期:2011-01-25 发布日期:2011-01-04
  • 通讯作者: YOU Tian-yan E-mail:youty@ciac.jl.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China(No.20875085) and the Fund of Chinese Academy of Sciences(No.KJCX2-YW-H11).

Enantiomeric Separation of Antidepressant Trimipramine by Capillary Electrophoresis Combined with Electrochemiluminescence Detection in Aqueous-organic Media

YU Cai-xia1,2, YUAN Bai-qing1 and YOU Tian-yan1*   

  1. 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;
    2. Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China
  • Received:2010-02-09 Revised:2010-04-28 Online:2011-01-25 Published:2011-01-04
  • Contact: YOU Tian-yan E-mail:youty@ciac.jl.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20875085) and the Fund of Chinese Academy of Sciences(No.KJCX2-YW-H11).

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摘要： The antidepressant trimipramine(Tri) enantiomers were successfully separated by capillary electrophoresis(CE) coupled with electrochemiluminescence(ECL) detection in aqueous-organic media. A dual cyclodextrin(CD) system combining β-CD and hydroxypropyl-β-cyclodextrin(HP-β-CD) was used as chiral selector. Acetonitrile(ACN) was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.

关键词: Capillary electrophoresis, Electrochemiluminescence, Trimipramine, Enantioseparation, Organic additive

Abstract: The antidepressant trimipramine(Tri) enantiomers were successfully separated by capillary electrophoresis(CE) coupled with electrochemiluminescence(ECL) detection in aqueous-organic media. A dual cyclodextrin(CD) system combining β-CD and hydroxypropyl-β-cyclodextrin(HP-β-CD) was used as chiral selector. Acetonitrile(ACN) was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.

Key words: Capillary electrophoresis, Electrochemiluminescence, Trimipramine, Enantioseparation, Organic additive