Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

高等学校化学研究 ›› 2011, Vol. 27 ›› Issue (5): 808-812.

Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

CUI Lin-lin¹, MI Hao-yu¹, ZHANG Qun-li¹, WANG Wei-wei², YANG Li-juan², LIANG Yong-tao^1* and WANG En-si^1,2*

1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. College of Pharmacy, Jilin University, Changchun 130021, P. R. China

收稿日期:2010-07-13 修回日期:2010-11-17 出版日期:2011-09-25 发布日期:2011-09-06
通讯作者: WANG En-si;LIANG Yong-tao E-mail:wangss@jlu.edu.cn; liangyongtao2005@126.com

Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

CUI Lin-lin¹, MI Hao-yu¹, ZHANG Qun-li¹, WANG Wei-wei², YANG Li-juan², LIANG Yong-tao^1* and WANG En-si^1,2*

1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. College of Pharmacy, Jilin University, Changchun 130021, P. R. China

Received:2010-07-13 Revised:2010-11-17 Online:2011-09-25 Published:2011-09-06
Contact: WANG En-si;LIANG Yong-tao E-mail:wangss@jlu.edu.cn; liangyongtao2005@126.com

摘要/Abstract

摘要： A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.

关键词: Immunosuppressant, Amino alcohol derivative, Bioactivity, Buchere-Bergs reaction

Abstract: A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.

Key words: Immunosuppressant, Amino alcohol derivative, Bioactivity, Buchere-Bergs reaction

CUI Lin-lin, MI Hao-yu, ZHANG Qun-li, WANG Wei-wei, YANG Li-juan, LIANG Yong-tao. Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)[J]. 高等学校化学研究, 2011, 27(5): 808-812.

CUI Lin-lin, MI Hao-yu, ZHANG Qun-li, WANG Wei-wei, YANG Li-juan, LIANG Yong-tao* and WANG En-si*. Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)[J]. Chemical Research in Chinese Universities, 2011, 27(5): 808-812.

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Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

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