Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth

高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (5): 757-760.

Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth

ZHANG Zhong-bo3, FU Shi-bo2, DUAN Hai-feng1, LIN Ying-jie1* and YANG Ying2*

1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
2. Key Lab of Radiobiology, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, P. R. China;
3. College of Environmental and Resource, Jilin University, Changchun 130012, P. R. China

收稿日期:2009-10-23 修回日期:2009-12-15 出版日期:2010-09-25 发布日期:2010-11-26
通讯作者: LIN Ying-jie. E-mail: linyj@jlu.edu.cn; YANG Ying. E-mail: yangy2002@yahoo.com

Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth

ZHANG Zhong-bo3, FU Shi-bo2, DUAN Hai-feng1, LIN Ying-jie1* and YANG Ying2*

1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
2. Key Lab of Radiobiology, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, P. R. China;
3. College of Environmental and Resource, Jilin University, Changchun 130012, P. R. China

Received:2009-10-23 Revised:2009-12-15 Online:2010-09-25 Published:2010-11-26
Contact: LIN Ying-jie. E-mail: linyj@jlu.edu.cn; YANG Ying. E-mail: yangy2002@yahoo.com

摘要/Abstract

摘要： An investigation into the effect of several novel well-designed guanidinium salt ionic liquids(GILs) on inhibitting tumor growth is described. The GILs which have longer alkyl chain(6―18 carbon atoms) exhibit the high cytotoxicity to Hela299, B16 and SMMC-7721 cells so as to inhibit their proliferation. The inhibitory effect of the most effective GIL12 is about 10-fold higher than that of MMC(a common chemotherapy drug in clinic).

关键词: Ionic liquid, Inhibitor, Tumor, Cell

Abstract: An investigation into the effect of several novel well-designed guanidinium salt ionic liquids(GILs) on inhibitting tumor growth is described. The GILs which have longer alkyl chain(6―18 carbon atoms) exhibit the high cytotoxicity to Hela299, B16 and SMMC-7721 cells so as to inhibit their proliferation. The inhibitory effect of the most effective GIL12 is about 10-fold higher than that of MMC(a common chemotherapy drug in clinic).

Key words: Ionic liquid, Inhibitor, Tumor, Cell

ZHANG Zhong-bo3, FU Shi-bo2, DUAN Hai-feng1, LIN Ying-jie1* and YANG Ying2* . Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth[J]. 高等学校化学研究, 2010, 26(5): 757-760.

ZHANG Zhong-bo3, FU Shi-bo2, DUAN Hai-feng1, LIN Ying-jie1* and YANG Ying2* . Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth[J]. Chemical Research in Chinese Universities, 2010, 26(5): 757-760.

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Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth

Brand-new Function of Well-designed Ionic Liquid: Inhibitor of Tumor Cell Growth

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