高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (2): 268-271.
Synthesis and Anti-inflammatory Activity of a Novel Series of 9,10-Dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one Derivatives
LIU Xiao-ping1, WANG Ying2, LAN Hui-yu2, SONG Ai-hua1, TSIM Karl Wah-keung3, DONG Tina Ting-xia3 and HU Chun1*
- 1. Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;
2. Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P. R. China;
3. Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China
Synthesis and Anti-inflammatory Activity of a Novel Series of 9,10-Dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one Derivatives
LIU Xiao-ping1, WANG Ying2, LAN Hui-yu2, SONG Ai-hua1, TSIM Karl Wah-keung3, DONG Tina Ting-xia3 and HU Chun1*
- 1. Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;
2. Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P. R. China;
3. Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China
摘要：
Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity, while some 1,3-benzoxazine derivatives show anti-inflammatory activity. In order to explore the novel anti-inflammatory agents, based on the principles of bioisosterism and hybridization, ten novel chromeno[8,7-e][1,3]oxazin-4-ones were synthesized and characterized with IR, 1H NMR, MS and elemental analyses. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, some target compounds show potent anti-inflammatory activity.