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高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (2): 245-248.

• Articles • 上一篇    下一篇

Facile Synthesis of 5-Hydroxy-2-(2-phenylethyl)chromone

ZHANG Lan-ping and WANG Ya-lou*   

  1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
  • 收稿日期:2009-04-09 修回日期:2009-04-23 出版日期:2010-03-25 发布日期:2010-05-25
  • 通讯作者: WANG Ya-lou. E-mail: wang_yalou@tom.com

Facile Synthesis of 5-Hydroxy-2-(2-phenylethyl)chromone

ZHANG Lan-ping and WANG Ya-lou*   

  1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
  • Received:2009-04-09 Revised:2009-04-23 Online:2010-03-25 Published:2010-05-25
  • Contact: WANG Ya-lou. E-mail: wang_yalou@tom.com

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摘要：

5-Hydroxy-2-(2-phenylethyl)chromone(1) was synthesized from 2,6-dihydroxyacetophenone(7) obtained via four-steps resorcinol-reacting with phenylpropionic acid, the procedures involved are Baker-Venkataraman rearrangement and cyclization which are easy to conduct, the overall yield is 32%.

关键词: 5-Hydroxy-2-(2-phenylethyl)chromone; Synthesis; Baker-Venkataraman rearrangement; Imperata cylindrica

Abstract:

5-Hydroxy-2-(2-phenylethyl)chromone(1) was synthesized from 2,6-dihydroxyacetophenone(7) obtained via four-steps resorcinol-reacting with phenylpropionic acid, the procedures involved are Baker-Venkataraman rearrangement and cyclization which are easy to conduct, the overall yield is 32%.

Key words: 5-Hydroxy-2-(2-phenylethyl)chromone; Synthesis; Baker-Venkataraman rearrangement; Imperata cylindrica