高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (2): 217-220.
Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice
ZHU Na1, QIAO Ying1, ZHANG Di1, WANG Wen-juan1, LIU Jia2, LIU Tian-zhou2 and MA Tong-hui1,2*
- 1. Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China;
2. Second Clinical Hospital, Jilin University, Changchun 130041, P. R. China
Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice
ZHU Na1, QIAO Ying1, ZHANG Di1, WANG Wen-juan1, LIU Jia2, LIU Tian-zhou2 and MA Tong-hui1,2*
- 1. Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China;
2. Second Clinical Hospital, Jilin University, Changchun 130041, P. R. China
摘要：
Aquaporins(AQPs) are molecular water channels that play important physiological roles in fluid transporting organs. The expression and function of AQPs in the immune system are largely unknown. CD11(a―d)/CD18 integrins are adhesion molecules expressed on leukocytes, which play a critical role in leukocyte adhesion, migration and host defense. In the present study, we discovered the expression of aquaporin-3(AQP3) on spleen CD11b positive cells, and the content of CD11b positive splenocytes in aquaporin 3-null mice is significantly decreased. Further analysis suggested remarkably decreased monocyte/macrophage subpopulation and significantly decreased granulocyte subpopulation. It is the first report suggesting an important role of AQP in the development and maturation of immunocytes.