Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

高等学校化学研究 ›› 2010, Vol. 26 ›› Issue (1): 66-69.

Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

QIU Xue-peng^1,2*, KOSOBE Toshiyuki¹ and KAWASHIMA Norimichi^1*

1. Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama 225-8502, Japan;
2. Laboratory of Polymer Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

收稿日期:2009-09-10 修回日期:2009-10-09 出版日期:2010-01-04 发布日期:2010-03-29
通讯作者: QIU Xue-peng, E-mail: xp_q@ciac.jl.cn; KAWASHIMA Norimichi, E-mail: kawasima@cc.toin.ac.jp
基金资助:
Supported Partly by the Academic Frontier Promotion Grant from the Ministry of Education, Science, Sports and Culture, Japan and the Exchange Program Between the Japan Society of the Promotion of Science and the Chinese Academy of Sciences.

Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

QIU Xue-peng^1,2*, KOSOBE Toshiyuki¹ and KAWASHIMA Norimichi^1*

1. Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama 225-8502, Japan;
2. Laboratory of Polymer Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2009-09-10 Revised:2009-10-09 Online:2010-01-04 Published:2010-03-29
Contact: QIU Xue-peng, E-mail: xp_q@ciac.jl.cn; KAWASHIMA Norimichi, E-mail: kawasima@cc.toin.ac.jp
Supported by:
Supported Partly by the Academic Frontier Promotion Grant from the Ministry of Education, Science, Sports and Culture, Japan and the Exchange Program Between the Japan Society of the Promotion of Science and the Chinese Academy of Sciences.

摘要/Abstract

摘要：

A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy(PDT) of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PpIX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates(C5-S, C6-S, C8-S) exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application of PpIX-mediated PDT to cancer cell.

关键词: Photodynamic therapy; Methanesulfonate salt; 5-Aminolevulinic acid; Derivative; Cancer cell

Abstract:

Key words: Photodynamic therapy; Methanesulfonate salt; 5-Aminolevulinic acid; Derivative; Cancer cell

QIU Xue-peng*, KOSOBE Toshiyuki and KAWASHIMA Norimichi*. Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives[J]. 高等学校化学研究, 2010, 26(1): 66-69.

QIU Xue-peng*, KOSOBE Toshiyuki and KAWASHIMA Norimichi1*. Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives[J]. Chemical Research in Chinese Universities, 2010, 26(1): 66-69.

参考文献

[1] Dougherty T. J., Gomer C. J., Henderson B. W., et al., J. Natl. Cancer Inst., 1998, 90, 889
[2] Kurwa H. A., Barlow R. J., Clin. Exp. Dermatol., 1999, 24, 143
[3] Wu S. M., Ren Q. G., Zhou M. O., et al., Cancer Lett., 2003, 200, 123
[4] van den Akker J. T., Holroyd J. A., Vernon D. I., et al., Laser Surg. Med., 2003, 33, 173
[5] Ziokowski P., Osiecka B. J., Oremek G., et al., J. Exp. Ther. Oncol., 2004, 4, 121
[6] Pollock B., Turner D., Stringer M. R., et al., Br. J. Dernatol., 2004, 151, 616
[7] Uzdensky A. B., Juzeniene A., Kolpakova E., et al., Biochem. Biophys. Res. Commun., 2004, 322, 452
[8] Zhang S. J., Zhang Z. X., Photochem. Photobiol., 2004, 79, 545
[9] Nadeau V., O’Dwyer M., Hamdan K., et al., Photodermatol. Photimmunol. Photomed., 2004, 20, 170
[10] Ahmad S., McCarron P. A., Donnelly R. F., et al., Exp. Dermatol., 2004, 13, 445
[11] Chena H. M., Chenc C. T., Yang H., et al., Oral Oncology, 2004, 40, 630
[12] Tsai T., Hong R. L., Tsai J. C., et al., Lasers Surg. Med., 2004, 34, 62
[13] Castano A. P., Mroz P., Hamblin M. R., Nature Rev. Cancer, 2006, 6, 535
[14] Tope P. D., Ross E. V., Kollias N., et al., Photochem. Photobiol., 1998, 67, 249
[15] Kojima C., Toi Y., Harada A., et al., Bioconjugate Chem., 2007, 18, 663
[16] Recio E. D., Zambrano B., Alonso M. L., et al., Int. J. Dermatol., 2008, 47, 410
[17] Yang S. J., Shieh M. J., Lin F. H., et al., Cancer Lett., 2009, 273, 210
[18] Auner B. G., Valenta C., Hadgraft J., Int. J. Pharm., 2003, 255, 109
[19] Cairnduff F., Stringer M. R., Hudson E. J., et al., Br. J. Cancer, 1994, 69, 605
[20] MacDonald I. J., Dougherty T. J., J. Porphyrins Phtalocyanines, 2001, 5, 105
[21] Boyle R. W., Dolphin D., Photochem. Photobiol., 1996, 64, 469
[22] Wulf H. C., Philipsen P., Br. J. Dermatol., 2004, 150, 143
[23] El Khatib S., Didelon J., Leroux A., et al., J. Urol., 2004, 172, 2013
[24] De Rosa F. S., Lopez R. F., Thomazine J. A., et al., Pharm. Res., 2004, 21, 2247
[25] Kristiansson S., Juzeniene A., Juzenas P., et al., Photochem. Photobiol., 2005, 81, 394
[26] Tan B., Sinclair R., Foley P., Australas. J. Dermatol., 2004, 45, 172
[27] Gerscher S., Connelly J. P., Griffiths J., et al., Photochem. Photobiol., 2000, 72, 569
[28] Zenzen V., Zankl H., Mutat. Res., 2004, 561, 91
[29] Kosobe T., Fujikura Y., Tokuoka Y., et al., Photomed. Photobiol., 2002, 24, 19
[30] Rosa F. S. D., Lopez R. F., Thomazine J. A., et al., Pharm. Res., 2004, 21, 2247
[31] Kosobe T., Ph. D. Dissertation, Toin University of Yokohama, Japan, 2006

Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价