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高等学校化学研究 ›› 2009, Vol. 25 ›› Issue (6): 876-881.

• Articles • 上一篇    下一篇

Knoevenagel Condensation Catalyzed by DBU Brönsted Ionic Liquid without Solvent

YING An-guo1,2, LIU Luo1,2, WU Guo-feng1,2, CHEN Xin-zhi1*, YE Wei-dong2*, CHEN Jian-hui2 and ZHANG Kai-yuan2   

  1. 1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
    2. Xinchang Pharmaceuticals Factory, Zhejiang Medicine Co., Ltd., Xinchang 312500, P. R. China
  • 收稿日期:2008-11-12 修回日期:2008-12-01 出版日期:2009-11-25 发布日期:2010-01-25
  • 通讯作者: CHEN Xin-zhi, E-mail: xzchen@zju.edu.cn; YE Wei-dong, E-mail: yewd@xcpharma.com
  • 基金资助:

    Supported by the National Natural Science Foundation of China(No.20776127) and the National Key Technology Research and Development Program of China(No.2007BAI34B07).

Knoevenagel Condensation Catalyzed by DBU Brönsted Ionic Liquid without Solvent

YING An-guo1,2, LIU Luo1,2, WU Guo-feng1,2, CHEN Xin-zhi1*, YE Wei-dong2*, CHEN Jian-hui2 and ZHANG Kai-yuan2   

  1. 1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
    2. Xinchang Pharmaceuticals Factory, Zhejiang Medicine Co., Ltd., Xinchang 312500, P. R. China
  • Received:2008-11-12 Revised:2008-12-01 Online:2009-11-25 Published:2010-01-25
  • Contact: CHEN Xin-zhi, E-mail: xzchen@zju.edu.cn; YE Wei-dong, E-mail: yewd@xcpharma.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20776127) and the National Key Technology Research and Development Program of China(No.2007BAI34B07).

Abstract:

A protocol for the Knoevenagel condensation of aromatic aldehydes with methylene compounds catalyzed by task specifed ionic liquid 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium lactate under solvent-free conditions has been developed. The reactions proceed at ambient temperature and the work-up procedures are very simple. Good to excellent yields could be obtained. The ionic liuid could be simply prepared and recycled efficiently.

Key words: Knoevenagel condensation; [DBU][Lac]; Ionic liquid; Aromatic aldehydes; Active methylene compound