Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis

doi:10.1007/s40242-024-3280-9

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (2): 213-224.doi: 10.1007/s40242-024-3280-9

Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis

ZHENG Ting¹, WANG Ying¹, LI Xianming³, LI Chenghui¹, WU Peng^1,2

1. Analytical & Testing Centre, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610064, P. R. China;
2. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P. R. China;
3. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610064, P. R. China

收稿日期:2023-12-22 修回日期:2024-01-29 出版日期:2024-04-01 发布日期:2024-03-27
通讯作者: LI Chenghui lichenghui@scu.edu.cn;WU Peng wupeng@scu.edu.cn
基金资助:
This work was supported by the National Natural Science Foundation of China (No. 22325403) and the Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University, China (No. 2022A02).

Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis

ZHENG Ting¹, WANG Ying¹, LI Xianming³, LI Chenghui¹, WU Peng^1,2

1. Analytical & Testing Centre, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610064, P. R. China;
2. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P. R. China;
3. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610064, P. R. China

Received:2023-12-22 Revised:2024-01-29 Online:2024-04-01 Published:2024-03-27
Contact: LI Chenghui lichenghui@scu.edu.cn;WU Peng wupeng@scu.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (No. 22325403) and the Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University, China (No. 2022A02).

摘要/Abstract

摘要： Accurate detection of biomarkers is essential for disease diagnosis. Although the highly sensitive fluorescence probes are feasible for the above goal, it is typically interfered by the auto-fluorescence and light scattering of the biological samples. Photochemical afterglow system (consisting of photosensitizer, afterglow substrate and emitter) based on cascade photochemical reactions exhibits long-lived luminescence (seconds to hours), thus avoiding background interference. With the assistance of polymers, such as polystyrene microspheres, the photochemical afterglow systems have been transformed into homogeneous and water-soluble nanoparticles, and used for in-vitro biomarker analysis. Here, we summarized the principle, preparation and applications of these afterglow nanoparticles, and evaluated their performance in clinical sample testing by comparing with other nanoparticle-based methods. Finally, several problems and possible solutions of afterglow nanoparticle-based methods in biomarker determination were also mentioned.

关键词: Photochemical afterglow, In-vitro analysis, Background-free detection, Biomarker

Abstract: Accurate detection of biomarkers is essential for disease diagnosis. Although the highly sensitive fluorescence probes are feasible for the above goal, it is typically interfered by the auto-fluorescence and light scattering of the biological samples. Photochemical afterglow system (consisting of photosensitizer, afterglow substrate and emitter) based on cascade photochemical reactions exhibits long-lived luminescence (seconds to hours), thus avoiding background interference. With the assistance of polymers, such as polystyrene microspheres, the photochemical afterglow systems have been transformed into homogeneous and water-soluble nanoparticles, and used for in-vitro biomarker analysis. Here, we summarized the principle, preparation and applications of these afterglow nanoparticles, and evaluated their performance in clinical sample testing by comparing with other nanoparticle-based methods. Finally, several problems and possible solutions of afterglow nanoparticle-based methods in biomarker determination were also mentioned.

Key words: Photochemical afterglow, In-vitro analysis, Background-free detection, Biomarker

ZHENG Ting, WANG Ying, LI Xianming, LI Chenghui, WU Peng. Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis[J]. 高等学校化学研究, 2024, 40(2): 213-224.

ZHENG Ting, WANG Ying, LI Xianming, LI Chenghui, WU Peng. Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis[J]. Chemical Research in Chinese Universities, 2024, 40(2): 213-224.

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Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis

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