Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

doi:10.1007/s40242-023-3204-0

高等学校化学研究 ›› 2023, Vol. 39 ›› Issue (6): 857-861.doi: 10.1007/s40242-023-3204-0

Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

Muhammad INAM¹, Moshirian-Farahi SAREH SADAT², and Wenjie CHEN^1,3

1. Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMOA Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P.R. China;
2. Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran;
3. Sydney Vital Translational Cancer Research Centre, Westbourne St, NSW 2065, Australia

收稿日期:2023-09-03 出版日期:2023-12-01 发布日期:2023-11-18
通讯作者: Muhammad INAM, Wenjie CHEN E-mail:2022390020@gzhmu.edu.cn;wenjie.chen1@hdr.mq.edu.au
基金资助:
This work was supported by the Guangdong Postdoctoral Start-up Fund, China (No. Q0301-082), the High-level University Construction Fund of Guangdong Province, China (Nos. 02-412-2202-2123, 02-410-2206298, 02-412-2302- 2122XM), the Fund from He Guangzhou Science and Technology Bureau, China (No. 202201010378), and the Open Project of State Key Laboratory of Respiratory Disease, China (No. SKLRD-OP-202409).

Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

Muhammad INAM¹, Moshirian-Farahi SAREH SADAT², and Wenjie CHEN^1,3

1. Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMOA Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P.R. China;
2. Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran;
3. Sydney Vital Translational Cancer Research Centre, Westbourne St, NSW 2065, Australia

Received:2023-09-03 Online:2023-12-01 Published:2023-11-18
Contact: Muhammad INAM, Wenjie CHEN E-mail:2022390020@gzhmu.edu.cn;wenjie.chen1@hdr.mq.edu.au
Supported by:
This work was supported by the Guangdong Postdoctoral Start-up Fund, China (No. Q0301-082), the High-level University Construction Fund of Guangdong Province, China (Nos. 02-412-2202-2123, 02-410-2206298, 02-412-2302- 2122XM), the Fund from He Guangzhou Science and Technology Bureau, China (No. 202201010378), and the Open Project of State Key Laboratory of Respiratory Disease, China (No. SKLRD-OP-202409).

摘要/Abstract

摘要： Host-guest inclusion complexes have been extensively studied for drug delivery applications. The host molecule, typically cyclodextrin, creates a cavity, in which the guest molecule, such as a drug, can be encapsulated. This encapsulation can protect the drug from degradation, improve its solubility and stability, and enhance its bioavailability. Moreover, host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of action. Various techniques, such as covalent bonding, non-covalent interactions, and self-assembly have been used to form these complexes. Host-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery systems. This mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex, highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.

关键词: Poor water solubility, Inclusion complex, Physicochemi-cal, Biopharmaceutical

Abstract: Host-guest inclusion complexes have been extensively studied for drug delivery applications. The host molecule, typically cyclodextrin, creates a cavity, in which the guest molecule, such as a drug, can be encapsulated. This encapsulation can protect the drug from degradation, improve its solubility and stability, and enhance its bioavailability. Moreover, host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of action. Various techniques, such as covalent bonding, non-covalent interactions, and self-assembly have been used to form these complexes. Host-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery systems. This mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex, highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.

Key words: Poor water solubility, Inclusion complex, Physicochemi-cal, Biopharmaceutical

Muhammad INAM, Moshirian-Farahi SAREH SADAT, and Wenjie CHEN. Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs[J]. 高等学校化学研究, 2023, 39(6): 857-861.

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Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

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