[an error occurred while processing this directive]

高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (4): 727-728.doi: 10.1007/s40242-020-0158-3

• • 上一篇    下一篇

Precise Functionalization of Remote C―H Bonds

LIU Zeshui, CHENG Honggang, ZHOU Qianghui   

  1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
  • 收稿日期:2020-05-27 修回日期:2020-05-28 出版日期:2020-08-01 发布日期:2020-05-27
  • 通讯作者: ZHOU Qianghui E-mail:qhzhou@whu.edu.cn

Precise Functionalization of Remote C―H Bonds

LIU Zeshui, CHENG Honggang, ZHOU Qianghui   

  1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
  • Received:2020-05-27 Revised:2020-05-28 Online:2020-08-01 Published:2020-05-27
  • Contact: ZHOU Qianghui E-mail:qhzhou@whu.edu.cn

摘要： Remote C-H bond functionalization of arenes with precise control is a recognized extraordinary challenge in organic synthesis. Recently, Yu and Houk et al. developed an elegant strategy to distinguish and functionalize remote Csp2-H bonds of (hetero)arenes within one-bond distance by the interplay of a remote directing template and a transient norbornene-type mediator. A wide range of medicinally important benzoazines are well compatible with this method. The chemistry significantly expands the toolbox for site-selective functionalization of remote Csp2-H bond of (hetero)arenes. This work has been published in Nature Chemistry in March, 2020.

Abstract: Remote C-H bond functionalization of arenes with precise control is a recognized extraordinary challenge in organic synthesis. Recently, Yu and Houk et al. developed an elegant strategy to distinguish and functionalize remote Csp2-H bonds of (hetero)arenes within one-bond distance by the interplay of a remote directing template and a transient norbornene-type mediator. A wide range of medicinally important benzoazines are well compatible with this method. The chemistry significantly expands the toolbox for site-selective functionalization of remote Csp2-H bond of (hetero)arenes. This work has been published in Nature Chemistry in March, 2020.