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高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (4): 731-732.doi: 10.1007/s40242-020-0057-7

• • 上一篇    

Towards Artificial Cells: Engineering Encapsulated Molecular Signaling with Intelligent DNA Nanomachines

LIU Dongsheng   

  1. Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
  • 收稿日期:2020-03-09 修回日期:2020-03-10 出版日期:2020-08-01 发布日期:2020-07-30
  • 通讯作者: LIU Dongsheng E-mail:liudongsheng@tsinghua.edu.cn

Towards Artificial Cells: Engineering Encapsulated Molecular Signaling with Intelligent DNA Nanomachines

LIU Dongsheng   

  1. Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
  • Received:2020-03-09 Revised:2020-03-10 Online:2020-08-01 Published:2020-07-30
  • Contact: LIU Dongsheng E-mail:liudongsheng@tsinghua.edu.cn

摘要： The building and engineering of an artificial molecular signaling system in encapsulated vesicles is a key step towards artificial cells. Recently, Tan et al. reached a new milestone by integrating an intelligent DNA nano- gatekeeper with an artificial vesicle system. The DNA nanogatekeeper driven by adenosine triphosphate(ATP) is able to receive outside stimulus, which in turn switches the diffusion of environmental ions into the integrated vesicle. Most importantly, this system enables triggering downstream signaling cascaded reactions confined in the artificial vesicle, as well as returning feedback to the DNA nanogatekeeper, mimicking real cellular behaviors of reception, transduction and response. This work has been published online in Nature Communications aon February 20, 2020.

Abstract: The building and engineering of an artificial molecular signaling system in encapsulated vesicles is a key step towards artificial cells. Recently, Tan et al. reached a new milestone by integrating an intelligent DNA nano- gatekeeper with an artificial vesicle system. The DNA nanogatekeeper driven by adenosine triphosphate(ATP) is able to receive outside stimulus, which in turn switches the diffusion of environmental ions into the integrated vesicle. Most importantly, this system enables triggering downstream signaling cascaded reactions confined in the artificial vesicle, as well as returning feedback to the DNA nanogatekeeper, mimicking real cellular behaviors of reception, transduction and response. This work has been published online in Nature Communications aon February 20, 2020.