Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

doi:10.1007/s40242-018-7302-3

高等学校化学研究 ›› 2018, Vol. 34 ›› Issue (1): 51-56.doi: 10.1007/s40242-018-7302-3

Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

XU Boxuan¹, DING Xiudong², WU Yachuang¹, CUI Lei², QIAN Ping¹, WANG Di², ZHAO Yanfang¹

1. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;
2. Department of Clinical Laboratory, the 309th Hospital of PLA, Beijing 100091, P. R. China

收稿日期:2017-09-12 出版日期:2018-02-01 发布日期:2018-01-20
通讯作者: ZHAO Yanfang,E-mail:yanfangzhao@126.com;WANG Di,E-mail:wangdi_42869@163.com E-mail:yanfangzhao@126.com;wangdi_42869@163.com
基金资助:
Supported by the Program for Innovative Research Team of the Ministry of Education of China, the Program for Liaoning Innovative Research Team in University, China(No.IRT1073) and the Basic Program of Liaoning Provincial Department of Education, China(No.2017LZD06).

Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

XU Boxuan¹, DING Xiudong², WU Yachuang¹, CUI Lei², QIAN Ping¹, WANG Di², ZHAO Yanfang¹

1. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;
2. Department of Clinical Laboratory, the 309th Hospital of PLA, Beijing 100091, P. R. China

Received:2017-09-12 Online:2018-02-01 Published:2018-01-20
Contact: ZHAO Yanfang,E-mail:yanfangzhao@126.com;WANG Di,E-mail:wangdi_42869@163.com E-mail:yanfangzhao@126.com;wangdi_42869@163.com
Supported by:
Supported by the Program for Innovative Research Team of the Ministry of Education of China, the Program for Liaoning Innovative Research Team in University, China(No.IRT1073) and the Basic Program of Liaoning Provincial Department of Education, China(No.2017LZD06).

摘要/Abstract

摘要： A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ¹H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.

关键词: Oxazolidinone derivative, Antibacterial activity, Linezolid, Ranbezolid

Abstract: A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ¹H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.

Key words: Oxazolidinone derivative, Antibacterial activity, Linezolid, Ranbezolid

XU Boxuan, DING Xiudong, WU Yachuang, CUI Lei, QIAN Ping, WANG Di, ZHAO Yanfang. Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety[J]. 高等学校化学研究, 2018, 34(1): 51-56.

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Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

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