[an error occurred while processing this directive]

高等学校化学研究 ›› 2017, Vol. 33 ›› Issue (6): 890-894.doi: 10.1007/s40242-017-7129-3

• Articles • 上一篇    下一篇

Total Synthesis and Biological Evaluation of Wewakazole

LONG Bohua1,2,3, ZHANG Jingzhao4, WANG Xueyan4, TANG Xudong4, WU Zhengzhi1,2,3   

  1. 1. The Fourth People's Hospital of Shenzhen, Shenzhen 518033, P. R. China;
    2. Shenzhen Institute of Geriatrics, Shenzhen 518020, P. R. China;
    3. The Second People's Hospital of Shenzhen, Shenzhen 518035, P. R. China;
    4. Key Lab for New Drug Research of TCM and Shenzhen Branch, State R & amp;D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, P. R. China
  • 收稿日期:2017-04-05 修回日期:2017-05-25 出版日期:2017-12-01 发布日期:2017-09-26
  • 通讯作者: LONG Bohua,E-mail:bhlong121@163.com E-mail:bhlong121@163.com
  • 基金资助:
    Support by the Health and Family Planning Commission of Shenzhen Municipality, China(No.201601053) and the Basic Research Project of Shenzhen Science and Technology Plan, China(No.JCYJ20160428110124165).

Total Synthesis and Biological Evaluation of Wewakazole

LONG Bohua1,2,3, ZHANG Jingzhao4, WANG Xueyan4, TANG Xudong4, WU Zhengzhi1,2,3   

  1. 1. The Fourth People's Hospital of Shenzhen, Shenzhen 518033, P. R. China;
    2. Shenzhen Institute of Geriatrics, Shenzhen 518020, P. R. China;
    3. The Second People's Hospital of Shenzhen, Shenzhen 518035, P. R. China;
    4. Key Lab for New Drug Research of TCM and Shenzhen Branch, State R & amp;D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, P. R. China
  • Received:2017-04-05 Revised:2017-05-25 Online:2017-12-01 Published:2017-09-26
  • Contact: LONG Bohua,E-mail:bhlong121@163.com E-mail:bhlong121@163.com
  • Supported by:
    Support by the Health and Family Planning Commission of Shenzhen Municipality, China(No.201601053) and the Basic Research Project of Shenzhen Science and Technology Plan, China(No.JCYJ20160428110124165).

摘要： The total synthesis of Wewakazole was achieved on a gram scale, unambiguously confirming its structure. Three different substituted oxazoles present in this natural product were prepared efficiently. Biological evaluation indicated that Wewakazole significantly inhibited cancer cell proliferation in a dose-dependent manner.

关键词: Wewakazole, Total synthesis, Biological evaluation

Abstract: The total synthesis of Wewakazole was achieved on a gram scale, unambiguously confirming its structure. Three different substituted oxazoles present in this natural product were prepared efficiently. Biological evaluation indicated that Wewakazole significantly inhibited cancer cell proliferation in a dose-dependent manner.

Key words: Wewakazole, Total synthesis, Biological evaluation