Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

doi:10.1007/s40242-017-7103-0

高等学校化学研究 ›› 2017, Vol. 33 ›› Issue (4): 569-573.doi: 10.1007/s40242-017-7103-0

Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

WANG Bowei¹, HOU Wanshi², WANG Yingnan², LI Shaoheng², LIU Zhihui³, SONG Zhiguang²

1. The Second Hospital, Jilin University, Changchun 130022, P. R. China;
2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Department of Prosthodontics, Stomatology Hospital of Jilin University, Changchun 130021, P. R. China

收稿日期:2017-03-16 修回日期:2017-04-06 出版日期:2017-08-01 发布日期:2017-07-19
通讯作者: Zhiguang E-mail:szg@jlu.edu.cn
基金资助:
Supported by the Development Project of the Pharmaceutical Industry of Jilin Province，China（Nos.20140311088YY，20150311070YY，20170307024YY），the Significant Science and Technology Project of Changchun City，China（No.2015054），the Key Science and Technology Project of Jilin Province，China（No.20140204066SF） and the Significant Science and Technology Item of-Double Ten Project‖ of Changchun City，China（No.16SS12）.

Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

WANG Bowei¹, HOU Wanshi², WANG Yingnan², LI Shaoheng², LIU Zhihui³, SONG Zhiguang²

1. The Second Hospital, Jilin University, Changchun 130022, P. R. China;
2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Department of Prosthodontics, Stomatology Hospital of Jilin University, Changchun 130021, P. R. China

Received:2017-03-16 Revised:2017-04-06 Online:2017-08-01 Published:2017-07-19
Contact: Zhiguang E-mail:szg@jlu.edu.cn
Supported by:
Supported by the Development Project of the Pharmaceutical Industry of Jilin Province，China（Nos.20140311088YY，20150311070YY，20170307024YY），the Significant Science and Technology Project of Changchun City，China（No.2015054），the Key Science and Technology Project of Jilin Province，China（No.20140204066SF） and the Significant Science and Technology Item of-Double Ten Project‖ of Changchun City，China（No.16SS12）.

摘要/Abstract

摘要：

Ibuprofen(IBU) and its derivatives are widely used in treating many diseases, such as depression, glomerulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibupr ofen-1-acetoxyethyl ester was synthesized in this paper. The maximum concentration(c_max) in a shorter time was compared with IBU at the same dose.

关键词: Ibuprofen, Ibuprofen-1-acetoxyethyl ester, Pharmacodynamic research

Abstract:

Key words: Ibuprofen, Ibuprofen-1-acetoxyethyl ester, Pharmacodynamic research

WANG Bowei, HOU Wanshi, WANG Yingnan, LI Shaoheng, LIU Zhihui, SONG Zhiguang. Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester[J]. 高等学校化学研究, 2017, 33(4): 569-573.

WANG Bowei, HOU Wanshi, WANG Yingnan, LI Shaoheng, LIU Zhihui, SONG Zhiguang. Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester[J]. Chemical Research in Chinese Universities, 2017, 33(4): 569-573.

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Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

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