Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

doi:10.1007/s40242-017-7112-z

高等学校化学研究 ›› 2017, Vol. 33 ›› Issue (5): 773-778.doi: 10.1007/s40242-017-7112-z

Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

SHEN Xizhou¹, HE Huajun^1,4, YANG Bowen², ZHAO Zhigang², SHAO Kaiyuan³, HU Wenxiang^1,3

1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430070, P. R. China;
2. College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, P. R. China;
3. Jingdong Xianghu Laboratory of Beijing Excalibur Space, Military Academy of Medical Sciences, Beijing 101601, P. R. China;
4. Food and Drugs Inspection & Testing Center of Jingning County, Jingning 323500, P. R. China

收稿日期:2017-03-27 修回日期:2017-05-16 出版日期:2017-10-01 发布日期:2017-07-03
通讯作者: HU Wenxiang,E-mail:huwx66@163.com E-mail:huwx66@163.com
基金资助:
Supported by the Beijing Municipal Special Fund Project, China(No.009-0753003); the National Science and Technology Innovation Fund Project of China(No.09C26211100074).

Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

SHEN Xizhou¹, HE Huajun^1,4, YANG Bowen², ZHAO Zhigang², SHAO Kaiyuan³, HU Wenxiang^1,3

1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430070, P. R. China;
2. College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, P. R. China;
3. Jingdong Xianghu Laboratory of Beijing Excalibur Space, Military Academy of Medical Sciences, Beijing 101601, P. R. China;
4. Food and Drugs Inspection & Testing Center of Jingning County, Jingning 323500, P. R. China

Received:2017-03-27 Revised:2017-05-16 Online:2017-10-01 Published:2017-07-03
Contact: HU Wenxiang,E-mail:huwx66@163.com E-mail:huwx66@163.com
Supported by:
Supported by the Beijing Municipal Special Fund Project, China(No.009-0753003); the National Science and Technology Innovation Fund Project of China(No.09C26211100074).

摘要/Abstract

摘要：

In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were synthesized with microwave irradiation in good yields to verify the quantitative analysis data. Friedel-Crafts acylation was carried out by the microwave method for the first time.

关键词: Quantum chemical calculation, Electrophilic site, Multiphilicity descriptor, Benzodiazepine, Electrophilic substitution reaction

Abstract:

Key words: Quantum chemical calculation, Electrophilic site, Multiphilicity descriptor, Benzodiazepine, Electrophilic substitution reaction

SHEN Xizhou, HE Huajun, YANG Bowen, ZHAO Zhigang, SHAO Kaiyuan, HU Wenxiang. Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor[J]. 高等学校化学研究, 2017, 33(5): 773-778.

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Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

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