Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

doi:10.1007/s40242-016-6164-9

高等学校化学研究 ›› 2016, Vol. 32 ›› Issue (5): 760-767.doi: 10.1007/s40242-016-6164-9

Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

WU Yi¹, ZHAO Yanping¹, GUO Jing¹, LÜ Haoze², ZHENG Nan¹, WANG Ensi¹

1. College of Pharmacy, Jilin University, Changchun 130021, P. R. China;
2. School of Clinical Medicine, Jilin University, Changchun 130021, P. R. China

收稿日期:2016-04-25 修回日期:2016-06-29 出版日期:2016-10-01 发布日期:2016-08-01
通讯作者: WANG Ensi E-mail:wangss@jlu.edu.cn
基金资助:
Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co., Ltd.

Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

WU Yi¹, ZHAO Yanping¹, GUO Jing¹, LÜ Haoze², ZHENG Nan¹, WANG Ensi¹

1. College of Pharmacy, Jilin University, Changchun 130021, P. R. China;
2. School of Clinical Medicine, Jilin University, Changchun 130021, P. R. China

Received:2016-04-25 Revised:2016-06-29 Online:2016-10-01 Published:2016-08-01
Contact: WANG Ensi E-mail:wangss@jlu.edu.cn
Supported by:
Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co., Ltd.

摘要/Abstract

摘要：

A series of amino alcohol derivatives containing 1,3,4-oxadiazole moieties was synthesized with 7-bromo-2-tetralone as starting materials, 2,2-dimethyl-1,3-oxazolidine as intermediates and Strecker reaction and cyclization with POCl₃ as key steps. The structures of the key intermediate and target compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS. Some compounds have resulted in the generation of highly potent sphingosine 1-phosphate receptor type 1(S1P₁) agonists.

关键词: Amino alcohol, 1,3,4-Oxadiazole, Bioactivity, Strecker reaction

Abstract:

Key words: Amino alcohol, 1,3,4-Oxadiazole, Bioactivity, Strecker reaction

WU Yi, ZHAO Yanping, GUO Jing, LÜ Haoze, ZHENG Nan, WANG Ensi. Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole[J]. 高等学校化学研究, 2016, 32(5): 760-767.

WU Yi, ZHAO Yanping, GUO Jing, LÜ Haoze, ZHENG Nan, WANG Ensi. Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole[J]. Chemical Research in Chinese Universities, 2016, 32(5): 760-767.

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Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

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