高等学校化学研究 ›› 2001, Vol. 17 ›› Issue (S1): 119-119.
Enantioselective Synthesis of Protease Inhibitors and Anti-HIV Agents
WANG Zhe
- DuPont Pharmaceuticals Company, Research & Development, Chambers Works, Deepwater, NJ 08023
Enantioselective Synthesis of Protease Inhibitors and Anti-HIV Agents
WANG Zhe
- DuPont Pharmaceuticals Company, Research & Development, Chambers Works, Deepwater, NJ 08023
摘要：
A highly enantio- and diastereoselective Ireland-Claisen rearrangement of chiral C3-(acyloxy)-vinyl silanes for the synthesis of anti-disubstituted succinic acid,an important intermediate for matrix metalloprolease inhibitors,has been developed(enantio- and anti/syn selectivities up to 95% and 38/1).