Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA

doi:10.1007/s40242-015-4198-z

高等学校化学研究 ›› 2015, Vol. 31 ›› Issue (1): 31-37.doi: 10.1007/s40242-015-4198-z

Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA

GE Shun, ZHAO Ying, SUI Beibei, SHANGGUAN Guoqiang

School of Biological Science, Jining Medical University, Rizhao 276826, P. R. China

收稿日期:2014-05-26 修回日期:2014-10-12 出版日期:2015-02-01 发布日期:2015-01-21
通讯作者: SHANGGUAN Guoqiang, E-mail:gqshangguan@mail.jnmc.edu.cn E-mail:gqshangguan@mail.jnmc.edu.cn
基金资助:
Supported by the Natural Science Foundation of Shandong Province, China(No.ZR2011HL003).

Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA

GE Shun, ZHAO Ying, SUI Beibei, SHANGGUAN Guoqiang

School of Biological Science, Jining Medical University, Rizhao 276826, P. R. China

Received:2014-05-26 Revised:2014-10-12 Online:2015-02-01 Published:2015-01-21
Contact: SHANGGUAN Guoqiang, E-mail:gqshangguan@mail.jnmc.edu.cn E-mail:gqshangguan@mail.jnmc.edu.cn
Supported by:
Supported by the Natural Science Foundation of Shandong Province, China(No.ZR2011HL003).

摘要/Abstract

摘要：

The affinity and mode of interaction of four novel organogermanium sesquioxides with calf thymus DNA(CT-DNA) and two synthetic oligonucleotides, d(AT)₂₂d(AT)₂₂ and d(GC)₂₂d(GC)₂₂, were investigated by a combination of absorption spectroscopy, DNA thermal denaturalization method, viscosity method, fluorometric technique, and competitive binding study with ethidium bromide(EB). The results show that the organogermanium compounds can interact with DNA by intercalation, the binding ability of the compounds to CT-DNA and the synthetic oligonucleotides was found to be modest(in comparison to the proven intercalators), with binding constants on the order of 10³―10⁵ L/mol, respectively. Generally, the binding of the organogermanium sesquioxides with naphthalene moiety to DNA is stronger than that of the compounds with anthraquinone moiety. And the compounds with anthraquinone moiety have preference for binding to AT-rich duplexes, whereas the compounds with naphthalene moiety have a little preference for binding to GC-rich duplexes. DNA may be the primary effect target.

关键词: Organogermanium sesquioxide, DNA, Interaction, Intercalation

Abstract:

Key words: Organogermanium sesquioxide, DNA, Interaction, Intercalation

GE Shun, ZHAO Ying, SUI Beibei, SHANGGUAN Guoqiang. Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA[J]. 高等学校化学研究, 2015, 31(1): 31-37.

GE Shun, ZHAO Ying, SUI Beibei, SHANGGUAN Guoqiang. Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA[J]. Chemical Research in Chinese Universities, 2015, 31(1): 31-37.

参考文献

[1] Tsutsui M., Kakimoto N., Axtell D. D., Oikawa H., Asai K., J. Am. Chem. Soc., 1976, 98, 8287
[2] Suzuki F., Cancer and Chemotherapy, 1985, 12, 1445
[3] Aso H., Suzuki F., Ebina T., Ishida N., J. Biol. Response Mod., 1989, 8, 180
[4] Suzuki F., Brutkiewicz R. R., Pollard R. B., Br. J. Cancer., 1985, 52, 757
[5] Suzuki F., Brutkiewicz R. R., Pollard R. B., Anticancer Res., 1985, 5, 479
[6] Nakamura K., Nomoto K., Osawa T., Takahashi Y., Akiba M., Kakimoto N., J. Chem. Soc. Japan, 1994, (3), 307
[7] Shangguan G. Q., Xing F. F., Qu X. G., Mao J. H., Zhao D., Zhao X. J., Ren J. S., Bioorg. Med. Chem. Lett., 2005, 15(12), 2962
[8] Zhang C. L., Li T. H., Niu S. H., Wang R. F., Fu Z. L., Guo F. Q., Yang M., Bioinorg. Chem. Appl., 2009, 2009(2), 1
[9] Choi S., Oh C., Han J., Park J., Eur. J. Med. Chem., 2010, 45(4), 1654
[10] Yang F., Jin H., Pi J., Jiang J. H., Liu L., Bai H. H., Yang P. H, Cai J. Y., Bioorg. Med. Chem. Lett., 2013, 23(20), 5544
[11] Shangguan G. Q., Huang L. L., Qu X. G., Chin. Chem. Lett., 2007, 18(11), 1347
[12] Chen G. J., Qiao X., Qiao P. Q., Xu G. J., Xu J. Y., Tian J. L., Gu W., Liu X., Yan S. P., J. Inorg. Biochem., 2011, 105, 119
[13] Zuber G., Quada J. C., Hecht S. M., J. Am. Chem. Soc., 1998, 120, 9368
[14] Hurley L. H., Boyd F. L., Trends Pharmacol. Sci., 1988, 11, 402
[15] Gottesfeld J. M., Neely L., Trauger J. W., Baird E. E., Dervan P. B., Nature, 1997, 387, 202
[16] Chaires J. B., Curr. Opin. Struct. Biol., 1998, 3, 314
[17] Wolkenberg S. E., Boger D. L., Chem. Rev., 2002, 102, 2477
[18] Wells R. D., Larson J. E., Grant R. C., Shortle B. E., Cantor C. R., J. Mol. Biol., 1970, 54, 465
[19] Borer P. N.; Ed.: Fasman G. D., Handbook of Biochemistry and Molecular Biology, Nucleic Acids, 3rd Ed., CRC Press, Boca Raton, 1975, 152, 589
[20] Bailly C., Qu X. G., Graves D. E., Prudehomme M., Chaires J. B., Chem. Biol., 1999, 6, 277
[21] Bailly C., Qu X. G., Chaires J. B., Colson P., Houssier C., Ohkubo M., Nishimura S., Yoshinari T., J. Med. Chem., 1999, 42(15), 2927
[22] Job P., Ann. Chim., 1928, 9, 113
[23] Wang K., Lin X., Wan X., Jia T., Zhang X. L., Zhang H., Ju X. L., Chem. J. Chinese Universities, 2012, 33(12), 2663
[24] Li J. F., Shi W. T., Han X. Y., Dong C., Choi M. M. F., Chem. Res. Chinese Universities, 2012, 28(4), 614
[25] Zhang G. W., Zhang Y. P., Zhang Y., Li Y., Sensors and Actuators B: Chemical, 2013, 182, 453
[26] Kumar C. V., Asuncion E. H., J. Am. Chem. Soc., 1993, 115, 8547
[27] Kelly T. M., Tossi A. B., McConnell D. J., Strekas T. C., Nucleic Acid Res., 1985, 13(17), 6017
[28] Long E. C., Bart J. K., Acc. Chem. Res., 1990, 23 (9), 271
[29] Heater S. J., Carrano M. W., Rains D., Walter R. B., Inorg. Chem., 2000, 39, 3881
[30] Goossens J. F., Bencteux E. B., Houssin R., Biochemistry, 2001, 40, 4663
[31] Satyanarayana S., Dabrowiak J. C., Chaires J. B., Biochemistry, 1992, 31(39), 9319
[32] Reynisson J., Schuster G. B., Howeerton S. B., Williams L. D., Barnett R. N., Cleveland C. L., Landman U., Harrit N., Chaires J. B., J. Am. Chem. Soc., 2003, 125(8), 2072
[33] Satyanara Y. S., Dabrowiak J. C., Chairs J. B., Biochemistry, 1993, 32, 2573
[34] Cohen G., Eisenberg H., Biopolymers, 1968, 6(8), 1077
[35] Cohen G., Eisenberg H., Biopolymers, 1969, 8(1), 45
[36] Lenman L. S., J. Mol. Biol., 1961, 3, 18
[37] Pecq J. B. L., Paoletti C. A., J. Mol. Biol., 1967, 27, 87
[38] Ihmels H., Otto D., Topics in Current Chemistry, 2005, 258, 161
[39] Tian Z. Y., Zhao Z. H., Zang F. L., Wang Y. Q, Wang C. J., Journal of Photochemistry and Photobiology B: Biology, 2014, 138, 202
[40] Ma Y. D., Pan J. H., Zhang G. W., Zhang Y., Journal of Photochemistry and Photobiology B: Biology, 2013, 126, 112
[41] Wang Q., Yang Z. Y., Qi G. F., Qin D. D., Eur. J. Med. Chem., 2009, 44, 2425
[42] Skyrianou K. C, Raptopoulou C. P., Psycharis V., Kessissoglou D. P., Psomas G., Polyhedron, 2009, 28, 3265

Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA

Studies on the Interaction of Novel Organogermanium Sesquioxides with DNA

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