Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides

doi:10.1007/s40242-014-3376-8

高等学校化学研究 ›› 2014, Vol. 30 ›› Issue (3): 409-414.doi: 10.1007/s40242-014-3376-8

Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides

ZHU Hongwei, WANG Baolei, ZHANG Xiulan, XIONG Lixia, YU Shujing, LI Zhengming

State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China

收稿日期:2013-09-09 修回日期:2013-10-09 出版日期:2014-06-01 发布日期:2014-05-24
通讯作者: WANG Baolei, LI Zhengming E-mail:wangbaolei@126.com;nkzml@vip.163.com
基金资助:
Supported by the National Basic Research Program of China(No.2010CB126106), the National Key Technologies Research and Development Program of China(No.2011BAE06B05-3) and the National Natural Science Foundation of China (No.21372133).

Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides

ZHU Hongwei, WANG Baolei, ZHANG Xiulan, XIONG Lixia, YU Shujing, LI Zhengming

State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2013-09-09 Revised:2013-10-09 Online:2014-06-01 Published:2014-05-24
Contact: WANG Baolei, LI Zhengming E-mail:wangbaolei@126.com;nkzml@vip.163.com
Supported by:
Supported by the National Basic Research Program of China(No.2010CB126106), the National Key Technologies Research and Development Program of China(No.2011BAE06B05-3) and the National Natural Science Foundation of China (No.21372133).

摘要/Abstract

摘要：

A series of novel 3-bromo-1-(3-chloropyridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides was synthesized by the reaction of pyrazole carbonyl chloride with each of substituted phenylhydroxyamines. The latter ones were prepared in good yields by reducing substituted nitrobenzene compounds with Zn/NH₄Cl reductant system in alcohol. Structures of the title compounds were determined by IR, ¹H NMR, and HRMS. Their insecticidal and fungicidal activities were evaluated by larvicidal test against oriental armyworm and the mycelium growth rate method, respectively.

关键词: N-Hydroxyl amide, N-Pyridylpyrazole, Insecticidal activity, Fungicidal activity

Abstract:

Key words: N-Hydroxyl amide, N-Pyridylpyrazole, Insecticidal activity, Fungicidal activity

ZHU Hongwei, WANG Baolei, ZHANG Xiulan, XIONG Lixia, YU Shujing, LI Zhengming. Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides[J]. 高等学校化学研究, 2014, 30(3): 409-414.

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Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides

Syntheses and Biological Activities of Novel 3-Bromo-1-(3-chloropy-ridin-2-yl)-N-hydroxy-N-aryl-1H-pyrazole-5-carboxamides

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