Inhibition of α/β-K6P2W18O62·10H2O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (5): 862-865 .

Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

HU Xi-yu¹, CHEN Bing-nian², WANG Li¹, CHEN Fa-he¹

1. School of Bioengineering, Jimei University, Xiamen 361021, P. R. China;
2. Yanwu Affiliated Hospital of Zhongshan Hospital, Xiamen University(Xiamen University Hospital), Xiamen 361005, P. R. China

收稿日期:2011-11-21 修回日期:2012-04-25 出版日期:2012-09-25 发布日期:2012-09-07
通讯作者: CHEN Bing-nian, WANG Li E-mail:wanglimerry@jmu.edu.cn; 18906008267@163.com
基金资助:
Supported by the National Natural Science Foundation of China(No.20871054) and the Science and Technology Foundation of Fujian Province, China(No.JK2011027, 2012J01045).

Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

HU Xi-yu¹, CHEN Bing-nian², WANG Li¹, CHEN Fa-he¹

1. School of Bioengineering, Jimei University, Xiamen 361021, P. R. China;
2. Yanwu Affiliated Hospital of Zhongshan Hospital, Xiamen University(Xiamen University Hospital), Xiamen 361005, P. R. China

Received:2011-11-21 Revised:2012-04-25 Online:2012-09-25 Published:2012-09-07
Supported by:
Supported by the National Natural Science Foundation of China(No.20871054) and the Science and Technology Foundation of Fujian Province, China(No.JK2011027, 2012J01045).

摘要/Abstract

摘要： Dawson-type phosphotungstic polyoxometalate α/β-K₆P₂W₁₈O₆₂·10H₂O(P₂W₁₈) was synthesized and its inhibitory effect on the mushroom tyrosinase was investigated. It could inhibit diphenolase activity of mushroom tyrosinase as an irreversible inhibitor. When the concentration of the enzyme reached 0.0176 mg/mL, the concentration of P₂W₁₈ leading to 50% activity lost(IC₅₀) was 0.05 mmol/L for monophenolase and 0.64 mmol/L for diphenolase. In addition, the antimicrobial activity of P₂W₁₈ was evaluated by zone of inhibition test. The results show that P₂W₁₈ possesses effective antimicrobial ability against Escherichia coli, Bacillus subtilis, yeast, especially Escherichia coli and yeast.

关键词: Polyoxometalate, Mushroom tyrosianse, Inhibition, Antimicrobial activity

Abstract: Dawson-type phosphotungstic polyoxometalate α/β-K₆P₂W₁₈O₆₂·10H₂O(P₂W₁₈) was synthesized and its inhibitory effect on the mushroom tyrosinase was investigated. It could inhibit diphenolase activity of mushroom tyrosinase as an irreversible inhibitor. When the concentration of the enzyme reached 0.0176 mg/mL, the concentration of P₂W₁₈ leading to 50% activity lost(IC₅₀) was 0.05 mmol/L for monophenolase and 0.64 mmol/L for diphenolase. In addition, the antimicrobial activity of P₂W₁₈ was evaluated by zone of inhibition test. The results show that P₂W₁₈ possesses effective antimicrobial ability against Escherichia coli, Bacillus subtilis, yeast, especially Escherichia coli and yeast.

Key words: Polyoxometalate, Mushroom tyrosianse, Inhibition, Antimicrobial activity

HU Xi-yu, CHEN Bing-nian, WANG Li, CHEN Fa-he. Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects[J]. 高等学校化学研究, 2012, 28(5): 862-865 .

HU Xi-yu, CHEN Bing-nian, WANG Li, CHEN Fa-he. Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects[J]. Chemical Research in Chinese Universities, 2012, 28(5): 862-865 .

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Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

Inhibition of α/β-K₆P₂W₁₈O₆₂·10H₂O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

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